Patterns of dendritic basal field orientation of pyramidal neurons in the rat somatosensory cortex

Leguey Vitoriano, Ignacio and Benavides Piccione, Ruth and Rojo, Concepción and Larrañaga Múgica, Pedro María and Bielza Lozoya, María Concepción and DeFelipe, Javier (2018). Patterns of dendritic basal field orientation of pyramidal neurons in the rat somatosensory cortex. "eNeuro", v. 5 (n. 6); pp. 1-13. ISSN 2373-2822. https://doi.org/10.1523/ENEURO.0142-18.2018.

Description

Title: Patterns of dendritic basal field orientation of pyramidal neurons in the rat somatosensory cortex
Author/s:
  • Leguey Vitoriano, Ignacio
  • Benavides Piccione, Ruth
  • Rojo, Concepción
  • Larrañaga Múgica, Pedro María
  • Bielza Lozoya, María Concepción
  • DeFelipe, Javier
Item Type: Article
Título de Revista/Publicación: eNeuro
Date: 2018
ISSN: 2373-2822
Volume: 5
Subjects:
Freetext Keywords: Pyramidal cell morphology; Circular statistics; Neuron orientation
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Inteligencia Artificial
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The study of neuronal dendritic orientation is of interest because it is related to how neurons grow dendrites to establish the synaptic input that neurons receive. The dendritic orientations of neurons in the nervous system vary, ranging from rather heterogeneously distributed (asymmetric) to homogeneously distributed (symmetric) dendritic arbors. Here, we analyze the dendritic orientation of the basal dendrites of intracellularly labeled pyramidal neurons from horizontal sections of Layers II–VI of the hindlimb somatosensory (S1HL) cortex of 14-d-old (P14) rats. We used circular statistics and proposed two new graphical descriptive representations of the neuron. We found that the dendritic pattern of most neurons was asymmetric. Furthermore, we found that there is a mixture of different types of orientations within any given group of neurons in any cortical layer. In addition, we investigated whether dendritic orientation was related to the physical location within the brain with respect to the anterior, dorsal, posterior and ventral directions. Generally, there was a preference towards the anterior orientation. A comparison between layers revealed that the preference for the anterior orientation was more pronounced in neurons located in Layers II, III, IV, and Va than for the neurons located in Layers Vb and VI. The dorsal orientation was the least preferred orientation in all layers, except for Layers IV and Va, where the ventral orientation had the lowest preference. Therefore, the orientation of basal dendritic arbors of pyramidal cells is variable and asymmetric, although a majority has a single orientation with a preference for the anterior direction in P14 rats.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainC080020-09UnspecifiedUnspecifiedCajal Blue Brain
Government of SpainTIN2016-796842-PUnspecifiedUnspecifiedUnspecified
Madrid Regional GovernmentS2013/ICE-2845CASI – CAMUnspecifiedConceptos y aplicaciones de los sistemas inteligentes
Horizon 2020785907HBP SGA2UnspecifiedHuman Brain Project Specific Grant Agreement 2

More information

Item ID: 54570
DC Identifier: http://oa.upm.es/54570/
OAI Identifier: oai:oa.upm.es:54570
DOI: 10.1523/ENEURO.0142-18.2018
Official URL: http://www.eneuro.org/content/eneuro/5/6/ENEURO.0142-18.2018.full.pdf
Deposited by: Memoria Investigacion
Deposited on: 09 May 2019 09:05
Last Modified: 09 May 2019 09:05
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