Injection laryngoplasty using autologous fat enriched with adipose-derived regenerative stem cells: a safe therapeutic option for the functional reconstruction of the glottal gap after unilateral vocal fold paralysis

Lasso Vázquez, José María and Poletti Serafini, Daniel and Scola Yurrita, Bartolomé and Gómez Vilda, Pedro and García Martín, Ana Isabel and Fernández Santos, María Eugenia (2018). Injection laryngoplasty using autologous fat enriched with adipose-derived regenerative stem cells: a safe therapeutic option for the functional reconstruction of the glottal gap after unilateral vocal fold paralysis. "Stem Cells International", v. 2018 ; pp. 1-15. ISSN 1687-966X. https://doi.org/https://doi.org/10.1155/2018/8917913.

Description

Title: Injection laryngoplasty using autologous fat enriched with adipose-derived regenerative stem cells: a safe therapeutic option for the functional reconstruction of the glottal gap after unilateral vocal fold paralysis
Author/s:
  • Lasso Vázquez, José María
  • Poletti Serafini, Daniel
  • Scola Yurrita, Bartolomé
  • Gómez Vilda, Pedro
  • García Martín, Ana Isabel
  • Fernández Santos, María Eugenia
Item Type: Article
Título de Revista/Publicación: Stem Cells International
Date: 2018
ISSN: 1687-966X
Volume: 2018
Subjects:
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Arquitectura y Tecnología de Sistemas Informáticos
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Paralysis of one vocal fold leads to glottal gap and vocal fold insufficiency that has significant impact upon a patient's quality of life. Fillers have been tested to perform intracordal injections, but they do not provide perdurable results. Early data suggest that enriching fat grafts with adipose-derived regenerative cells (ADRCs) promote angiogenesis and modulate the immune response, improving graft survival. The aim of this study is to propose ADRC-enriched adipose tissue grafts as effective filler for the paralyzed vocal fold to use it for functional reconstruction of the glottal gap. Method. This is the first phase I-IIA clinical trial (phase I/IIA clinical trial, unicentric, randomized, controlled, and two parallel groups), to evaluate the safety of a new therapy with ADRC-enriched fat grafting (ADRC: group I) for laryngoplasty after unilateral vocal fold paralysis. Control group patients received centrifuged autologous fat (CAF: group II) grafts. Overall mean age is 52.49 ± 16.60 years. Group I (ADRC): 7 patients (3 males and 4 females), 52.28 ± 20.95 year. Group II (CAF): 7 patients (3 males and 4 females), 52.71 ± 12.59 year. Results. VHI-10 test showed that preoperative mean score was 24.21 ± 8.28. Postoperative mean score was 6.71 ± 6.75. Preoperative result in group I was 21.14 ± 3.58 and postoperative result was 3.14 ± 3.53. Preoperative result for group II was 27.29 ± 10.66. Postoperative score in group II was 10.29 ± 7.52. Wilcoxon and the Student t-tests showed that the patient's self-perception of posttreatment improvement is larger when ADRCs are used. Comparing pre- and posttreatment voice quality analysis, group I showed a p = 0 053. Group II showed a p = 0 007. There would be no significant differentiation between pre- and posttreatment results. This is true for group II and limited for group I. Conclusions. This prospective trial demonstrates the safety and efficacy of the treatment of glottal gap defects utilizing ADRC-enriched fat grafts. This trial is registered with NCT02904824.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainTEC2012-38630-C04-01UnspecifiedUniversidad Politécnica de MadridEvaluación multimodal de trastornos neurológicos mediante la caracterización de la voz, dinámica de los pliegues vocales y secuencias sacádicas
Government of SpainTEC2012-38630-C04-04UnspecifiedUniversidad Politécnica de MadridDetección del trastorno neurológico por medio de correlatos de la fonación obtenidos por modelado inverso a partir de la fuente glótica
Government of SpainTRA-043UnspecifiedFundación Investigación Biomédica Hospital Gregorio MarañonTratamiento de la parálisis unilateral de cuerda vocal en incompetencia glótica, mediante inyección intracordal de células madre mesenquimales derivadas de tejido graso

More information

Item ID: 54663
DC Identifier: http://oa.upm.es/54663/
OAI Identifier: oai:oa.upm.es:54663
DOI: https://doi.org/10.1155/2018/8917913
Official URL: https://pdfs.semanticscholar.org/9ad0/02299a74418ccc1ae8407d6401ca2114463b.pdf?_ga=2.123390477.764512385.1557217006-4017405.1553688372
Deposited by: Memoria Investigacion
Deposited on: 07 May 2019 09:09
Last Modified: 07 May 2019 09:09
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