Research on the Methods for the Mass Production of Multi-Scale Organs-On-Chips

Díaz Lantada, Andrés and Pfleging, Wilhelm and Besser, Heino and Guttmann, Markus and Wissmann, Markus and Plewa, Klaus and Smyrek, Peter and Piotter, Volker and García-Ruíz, Josefa Predestinación (2018). Research on the Methods for the Mass Production of Multi-Scale Organs-On-Chips. "Polymers", v. 10 (n. 11); pp. 1-17. ISSN 2073-4360. https://doi.org/10.3390/polym10111238.

Description

Title: Research on the Methods for the Mass Production of Multi-Scale Organs-On-Chips
Author/s:
  • Díaz Lantada, Andrés
  • Pfleging, Wilhelm
  • Besser, Heino
  • Guttmann, Markus
  • Wissmann, Markus
  • Plewa, Klaus
  • Smyrek, Peter
  • Piotter, Volker
  • García-Ruíz, Josefa Predestinación
Item Type: Article
Título de Revista/Publicación: Polymers
Date: November 2018
ISSN: 2073-4360
Volume: 10
Subjects:
Freetext Keywords: organs-on-chips; labs-on-chips; additive manufacturing; laser materials processing; electroforming; mold fabrication; micro-injection molding; mass production; biomedical microdevices
Faculty: E.T.S.I. Industriales (UPM)
Department: Ingeniería Mecánica
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The success of labs- and organs-on-chips as transformative technologies in the biomedical arena relies on our capacity of solving some current challenges related to their design, modeling, manufacturability, and usability. Among present needs for the industrial scalability and impact promotion of these bio-devices, their sustainable mass production constitutes a breakthrough for reaching the desired level of repeatability in systematic testing procedures based on labs- and organs-on-chips. The use of adequate biomaterials for cell-culture processes and the achievement of the multi-scale features required, for in vitro modeling the physiological interactions among cells, tissues, and organoids, which prove to be demanding requirements in terms of production. This study presents an innovative synergistic combination of technologies, including: laser stereolithography, laser material processing on micro-scale, electroforming, and micro-injection molding, which enables the rapid creation of multi-scale mold cavities for the industrial production of labs- and organs-on-chips using thermoplastics apt for in vitro testing. The procedure is validated by the design, rapid prototyping, mass production, and preliminary testing with human mesenchymal stem cells of a conceptual multi-organ-on-chip platform, which is conceived for future studies linked to modeling cell-to-cell communication, understanding cell-material interactions, and studying metastatic processes.

Funding Projects

TypeCodeAcronymLeaderTitle
Horizon 2020644971FabSurfWARUnspecifiedDesign and Fabrication of Functional Surfaces with Controllable Wettability, Adhesion and Reflectivity

More information

Item ID: 54947
DC Identifier: http://oa.upm.es/54947/
OAI Identifier: oai:oa.upm.es:54947
DOI: 10.3390/polym10111238
Official URL: https://www.mdpi.com/2073-4360/10/11/1238/htm
Deposited by: Memoria Investigacion
Deposited on: 10 May 2019 13:41
Last Modified: 10 May 2019 13:41
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