LIFT bioprinting for the study of the immune response

Lauzurica Santiago, Sara and Márquez Fernández, Andrés and Molpeceres Álvarez, Carlos Luis and Gómez-Fontela, Miguel and Lauzurica, P. (2018). LIFT bioprinting for the study of the immune response. In: "Bioprinting & 3D-Printing in the Life Sciences EU 2018", 7-8 June 2018, Rotterdam, The Netherlands. p. 1.

Description

Title: LIFT bioprinting for the study of the immune response
Author/s:
  • Lauzurica Santiago, Sara
  • Márquez Fernández, Andrés
  • Molpeceres Álvarez, Carlos Luis
  • Gómez-Fontela, Miguel
  • Lauzurica, P.
Item Type: Presentation at Congress or Conference (Poster)
Event Title: Bioprinting & 3D-Printing in the Life Sciences EU 2018
Event Dates: 7-8 June 2018
Event Location: Rotterdam, The Netherlands
Title of Book: Bioprinting & 3D-Printing in the Life Sciences EU 2018
Date: June 2018
Subjects:
Faculty: E.T.S.I. Industriales (UPM)
Department: Física Aplicada e Ingeniería de Materiales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Immunology is a transversal field that is governed by a complex network of genetic and signalling pathways subtending a network of interacting cells. Laser bioprinting is a powerful tool to study complex biological systems like the ones that govern the immune response. The high accuracy and non-destructive nature of LIFT (Laser Induced Forward Transfer) is applied to the study of cell-cell interaction. In particular, single cell laser bioprinting helps to understand the relationship between the cell and their local environment. In this context, mobility of the cells in a network, along with their situation and the gene products they interact with, plays an important role in the behaviour of the immune system. In this work, we use a laser induced forward transfer blister assisted (BALIFT) approach to assess these cell-cell interactions in vitro. This method helps to understand properly the role of a cell within a network to increase our knowledge of the immune system response. This work presents BALIFT bioprinting of single hematopoietic cells with high spatial resolution. In particular, NK cells (natural killer) and T-lymphocyte are printed in different laser conditions and specific patterns to study cell viability and cell-cell interaction. By means of this technique, we can place cellular components on a previously designed matrix, allow us to test the molecular interactions between lymphocytes and pathogens.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainENE2016-78933-C4-4-RCHENOCUnspecifiedCélulas solares de heterounión de silicio de estructura no convencional

More information

Item ID: 55123
DC Identifier: http://oa.upm.es/55123/
OAI Identifier: oai:oa.upm.es:55123
Official URL: http://selectbiosciences.com/pastConferences/pastconferenceID.aspx?conf=B3DPLSEU2018
Deposited by: Memoria Investigacion
Deposited on: 27 May 2019 15:11
Last Modified: 09 Jun 2019 22:30
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