The immune repressor BIR1 contributes to antiviral defense and undergoes transcriptional and post-transcriptional regulation during viral infections

Guzmán Benito, Irene and Donaire, Livia and Amorim Silva, Vítor and Vallarino, José G. and Esteban, Alicia and Wierzbicki, Andrezj T. and Ruiz Ferrer, Virginia and Llave, César (2019). The immune repressor BIR1 contributes to antiviral defense and undergoes transcriptional and post-transcriptional regulation during viral infections. "New Phytologist", v. 224 (n. 1); pp. 421-438. ISSN 0028-646X. https://doi.org/10.1111/nph.15931.

Description

Title: The immune repressor BIR1 contributes to antiviral defense and undergoes transcriptional and post-transcriptional regulation during viral infections
Author/s:
  • Guzmán Benito, Irene
  • Donaire, Livia
  • Amorim Silva, Vítor
  • Vallarino, José G.
  • Esteban, Alicia
  • Wierzbicki, Andrezj T.
  • Ruiz Ferrer, Virginia
  • Llave, César
Item Type: Article
Título de Revista/Publicación: New Phytologist
Date: October 2019
ISSN: 0028-646X
Volume: 224
Subjects:
Freetext Keywords: Antiviral defense; BAK1; BIR1; plant innate immunity; plant viruses; post-transcriptional silencing; RNA-directed DNA methylation; SOBIR1
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

BIR1 is a receptor-like kinase that functions as a negative regulator of basal immunity and cell death in Arabidopsis. ? Using Arabidopsis thaliana and Tobacco rattle virus (TRV), we investigate the antiviral role of BIR1, the molecular mechanisms of BIR1 gene expression regulation during viral infections, and the effects of BIR1 overexpression on plant immunity and development. ? We found that SA acts as a signal molecule for BIR1 activation during infection. Inactivating mutations of BIR1 cause strong antiviral resistance that is not due to constitutive cell death or SA defense priming in the bir1-1 mutant. RNA-directed DNA methylation (RdDM) and posttranscriptional silencing are both required to negatively regulate BIR1 expression upon viral induction. BIR1 overexpression causes severe developmental defects, cell death and premature death that correlate with the constitutive activation of plant immune responses.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainBES-2013-063138UnspecifiedUnspecifiedFPI
Government of SpainEEBB-I-16-10815UnspecifiedUnspecifiedFPI
Government of SpainRyC-2011-07006UnspecifiedUnspecifiedUnspecified
Government of SpainBIO2012-39973UnspecifiedUnspecifiedNodos reguladores mediados por silenciamiento por RNA e inducibles por virus y evolución de marcas epigenéticas asociadas a la interacción planta-virus
Government of SpainBIO2015-70752-RUnspecifiedUnspecifiedInteracción cruzada entre silenciamiento genético e inmunidad innata basal durante las infecciones virales en las plantas

More information

Item ID: 55450
DC Identifier: http://oa.upm.es/55450/
OAI Identifier: oai:oa.upm.es:55450
DOI: 10.1111/nph.15931
Official URL: https://nph.onlinelibrary.wiley.com/doi/abs/10.1111/nph.15931
Deposited by: Memoria Investigacion
Deposited on: 11 Sep 2019 12:33
Last Modified: 11 Sep 2019 12:33
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