Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model

Casanova Carvajal, Oscar Ernesto Simón and Urbano Bojorge, Ana Lorena and Ramos Gómez, Milagros and Serrano Olmedo, José Javier and Martínez Murillo, Ricardo (2019). Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model. "Nanotechnology", v. 30 (n. 35); pp. 1-12. ISSN 0957-4484. https://doi.org/10.1088/1361-6528/ab2164.

Description

Title: Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model
Author/s:
  • Casanova Carvajal, Oscar Ernesto Simón
  • Urbano Bojorge, Ana Lorena
  • Ramos Gómez, Milagros
  • Serrano Olmedo, José Javier
  • Martínez Murillo, Ricardo
Item Type: Article
Título de Revista/Publicación: Nanotechnology
Date: 2019
ISSN: 0957-4484
Volume: 30
Subjects:
Freetext Keywords: CT-2A cells; glioblastoma; gold nanorods; hyperthermia; syngeneic mouse
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Metallic nanorods are promising agents for a wide range of biomedical applications. We report an optical hyperthermia method capable of inducing slowdown tumor progression of an experimental in vivo CT-2A glioblastoma tumor. The tumor model used in this research is based on the transplantation of mouse astrocytoma CT-2A cells in the striatum of mice by intracranial stereotaxic surgery. Two weeks after cell implant, the resulting tumor is treated by irradiating intratumoral injected gold nanorods, biofunctionalized with CD133 antibody (B-GNRs), using a continuous wave laser. Nanoparticles convert the absorbed light into localized heat (reaching up to 44 °C) due to the effect of surface plasmon resonance. A significant slowdown in CT-2A tumor progression is evident, by histology and magnetic resonance imaging, at one (p = 0.03) and two weeks (p = 0.008) after irradiation treatment. A notable deceleration in tumor size (15%–75%) as compared to the control untreated groups, it is observed. Thus, laser irradiation of B-GNRs is found to be effective for the treatment of CT-2A tumor progression. Similarities between the pre-clinical CT-2A tumor model and the human astrocytoma disease, in terms of anatomy, metastatic behavior and histopathology, suggest that hyperthermic treatment by laser irradiation of B-GNRs administered into high-grade human astrocytoma might constitute a promising alternative treatment to limit the progression of this deadly disease.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainPGC2018-097531-B-I00UnspecifiedUnspecifiedUnspecified
Madrid Regional GovernmentB2017/BMD-3760NEUROCENTRO-CMUnspecifiedCentro tecnológico para el estudio y tratamiento integrado de los desórdenes neurológicos

More information

Item ID: 55585
DC Identifier: http://oa.upm.es/55585/
OAI Identifier: oai:oa.upm.es:55585
DOI: 10.1088/1361-6528/ab2164
Official URL: https://iopscience.iop.org/article/10.1088/1361-6528/ab2164
Deposited by: Memoria Investigacion
Deposited on: 01 Jul 2019 15:54
Last Modified: 01 Jul 2019 15:54
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