Characterisation of adipose-specific partial deletion of hormone-sensitive lipase during obesity

García Terrón, Ainhoa (2019). Characterisation of adipose-specific partial deletion of hormone-sensitive lipase during obesity. Proyecto Fin de Carrera / Trabajo Fin de Grado, E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM), Madrid.

Description

Title: Characterisation of adipose-specific partial deletion of hormone-sensitive lipase during obesity
Author/s:
  • García Terrón, Ainhoa
Contributor/s:
  • Mouisel, Etienne
  • Menoyo Luque, David
Item Type: Final Project
Degree: Grado en Biotecnología
Date: July 2019
Subjects:
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Producción Agraria
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Obesity is a global pandemic, and the rate of mortality due to associated pathologies, such as type 2 diabetes (T2D), is increasing every year. One of the most substantiated causes of obesity-induced T2D concerns the high amount of fatty acids (FA) delivered in the blood by a hypertrophic adipocyte. FA do not oxidize and therefore are accumulated in non-adipose organs, leading to insulin resistance (IR) (Large et al. 1998). Therefore, the study of lipid metabolism- related enzymes becomes increasingly important. Among them the lipolytic pathway and notably hormone-sensitive lipase (HSL), is the cornerstone of functional fat cell maintenance (Girousse et al. 2013). We attempted to advance in the development of a new mouse model characterized by a lipid specific HSL happloinsufficiency it order to progress in the study of this lipase. We have validated the model by obtaining mice with nearly half deletion of HSL specific to adipose tissues. Nevertheless, the tolerance tests results do not show noticeable differences between control and study group. Such genetic modification do not seem to have systemic metabolic effects.

More information

Item ID: 56984
DC Identifier: http://oa.upm.es/56984/
OAI Identifier: oai:oa.upm.es:56984
Deposited by: Biblioteca ETSI Agrónomos
Deposited on: 21 Oct 2019 13:51
Last Modified: 21 Oct 2019 13:51
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