Evaluación ex vivo del mesenterio y células de estirpe mieloide como fuente de Interleucina-6 en la regeneración hepática en ratones

Martín Núñez, Andrea (2019). Evaluación ex vivo del mesenterio y células de estirpe mieloide como fuente de Interleucina-6 en la regeneración hepática en ratones. Proyecto Fin de Carrera / Trabajo Fin de Grado, E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM), Madrid.

Description

Title: Evaluación ex vivo del mesenterio y células de estirpe mieloide como fuente de Interleucina-6 en la regeneración hepática en ratones
Author/s:
  • Martín Núñez, Andrea
Contributor/s:
  • Vaquero Martín, Javier
  • González-Melendi, Pablo
Item Type: Final Project
Degree: Grado en Biotecnología
Date: June 2019
Subjects:
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The mesentery is an adipose tissue associated with the small intestine and colon. Recent studies suggest that, in addition to classical functions such as intestine suspension and node of vascular connections, the mesentery also plays an important role in the systemic regulation of inflammatory processes, like liver regeneration. Interleukin 6 (IL-6) is a pleiotropic protein that plays both anti- and pro-inflammatory roles in the response of liver regeneration. It has been described that, after a partial hepatectomy (PH), levels of IL-6 increase in bloodstream indicating that this cytokine plays a key role in liver regeneration. Traditionally, Kupffer cells (liver tissue macrophages) have been considered as the main source of IL-6 production after a PH. Nevertheless, studies carried out in the last few years, suggest the contribution of other cells, including hepatocytes, to IL-6 production. Moreover, the existence of extrahepatic IL-6 sources including the mesentery, have also been proposed. In this Final Degree Project, an ex vivo mesentery culture model has been developed with the aim of studying the production of IL-6 by this tissue. The results suggest that myeloid cells, in which Kupffer cells are included, are not the main cell source of IL-6 production in an inflammatory situation in the mesentery.

More information

Item ID: 57046
DC Identifier: http://oa.upm.es/57046/
OAI Identifier: oai:oa.upm.es:57046
Deposited by: Biblioteca ETSI Agrónomos
Deposited on: 24 Oct 2019 08:03
Last Modified: 24 Oct 2019 10:10
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