Consecuencias funcionales y cognitivo-afectivas a largo plazo del infarto cerebral arterial isquémico neonatal en un modelo en rata

Gallego Amaro, Ianire (2019). Consecuencias funcionales y cognitivo-afectivas a largo plazo del infarto cerebral arterial isquémico neonatal en un modelo en rata. Proyecto Fin de Carrera / Trabajo Fin de Grado, E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM), Madrid.

Description

Title: Consecuencias funcionales y cognitivo-afectivas a largo plazo del infarto cerebral arterial isquémico neonatal en un modelo en rata
Author/s:
  • Gallego Amaro, Ianire
Contributor/s:
  • Fernández Ruiz, Javier
  • Moreno Risueño, Miguel Ángel
Item Type: Final Project
Degree: Grado en Biotecnología
Date: June 2019
Subjects:
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img] PDF - Users in campus UPM only - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB)

Abstract

Arterial ischemic stroke is a pathology that frequently occurs during adulthood, nevertheless it might appear during perinatal period. Therefore, this stage must be considered as well especially susceptible to this disease because of the characteristics of an immature brain that makes it more sensitive to a stroke than an adult’s one. Physiopathology involves three main processes: inflammation, oxidative stress and excitotoxicity. These insults led to brain injury resulting in short and long-lasting motor, cognitive and affective impairment after birth. Post-stroke depression is a very common side-effect after the accident that has been well described in adults, however few important information has been obtained about its development after neonatal stroke. That explains the necessity to elaborate a follow-up study and monitor these patients from the first months of life, during adolescence and adulthood in order to find out whether stroke is an actual risk factor of depression. This would also help to improve their quality of life. The following study aims to understand the short- and long-term depressive behaviors in a rat model for neonatal stroke using middle cerebral artery occlusion (MCAO). Death cell and pro-inflammatory protein (TLR-4) levels were also evaluated to examine the possible involvement of the apoptosis and inflammation respectively in the observed depressive symptoms.

More information

Item ID: 57494
DC Identifier: http://oa.upm.es/57494/
OAI Identifier: oai:oa.upm.es:57494
Deposited by: Biblioteca ETSI Agrónomos
Deposited on: 13 Dec 2019 09:07
Last Modified: 13 Dec 2019 09:07
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM