Extreme variations in the ratios of non-synonymous to synonymous nucleotide substitution rates in signal peptide evolution

Garcia Maroto, Federico; Castagnaro, Atilio; Sanchez de la Hoz, Pilar; Maraña, Carmen; Carbonero Zalduegui, Pilar y García Olmedo, Francisco (1991). Extreme variations in the ratios of non-synonymous to synonymous nucleotide substitution rates in signal peptide evolution. "Febs Letters", v. 287 (n. 1-2); pp. 67-70. ISSN 0014-5793. https://doi.org/10.1016/0014-5793(91)80017-W.

Descripción

Título: Extreme variations in the ratios of non-synonymous to synonymous nucleotide substitution rates in signal peptide evolution
Autor/es:
  • Garcia Maroto, Federico
  • Castagnaro, Atilio
  • Sanchez de la Hoz, Pilar
  • Maraña, Carmen
  • Carbonero Zalduegui, Pilar
  • García Olmedo, Francisco
Tipo de Documento: Artículo
Título de Revista/Publicación: Febs Letters
Fecha: Agosto 1991
Volumen: 287
Materias:
Palabras Clave Informales: α-Amylase/trypsin inhibitor; Thaumatin II; Thionin; Plastocyanin; Signal peptide evolution
Escuela: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Departamento: Biotecnologia [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Nucleotide sequences encoding signal peptidcs from the precursors of α-amylase/trypsin inhibitors from cereals are homologous to those corresponding to the precursors of thaumatin II and of plastocyanins. Non-synonymous (KA) and synonymous (KS) rates of nucleotide substitutions have been calculated for all possible binary combinations. Extreme variation in KA/KS ratios has been observed, from the 0.167 average found within the plastocyanin family to an average of 1.90 calculated for the inhibitors/thaumatin II transition. A similar calculation has been carried out for the signal peptide sequences of thionins. which are unrelated to those of the α-amylase trypsin inhibitor family, and an average KA/KS of 0.12 has been obtained. This variation can be largely explained in terms of an empirical index of stability related to amino acid composition and seems to be independent of functional constraints.

Más información

ID de Registro: 5879
Identificador DC: http://oa.upm.es/5879/
Identificador OAI: oai:oa.upm.es:5879
Identificador DOI: 10.1016/0014-5793(91)80017-W
URL Oficial: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-44FMSTX-30&_user=885385&_coverDate=08/05/1991&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000047350&_version=1&_urlVersion=0&_userid=885385&md5=1a61d80ee767
Depositado por: Memoria Investigacion
Depositado el: 03 Feb 2011 09:22
Ultima Modificación: 20 Abr 2016 14:34
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