Modeling Living Cells Within Microfuidic Systems Using Cellular Automata Models

Ballesteros Hernando, Julia and Ramos Gomez, Milagros and Díaz Lantada, Andrés (2019). Modeling Living Cells Within Microfuidic Systems Using Cellular Automata Models. "Scientific Reports", v. 2019 (n. 9); pp. 1-10. ISSN 2045-2322. https://doi.org/10.1038/s41598-019-51494-1.

Description

Title: Modeling Living Cells Within Microfuidic Systems Using Cellular Automata Models
Author/s:
  • Ballesteros Hernando, Julia
  • Ramos Gomez, Milagros
  • Díaz Lantada, Andrés
Item Type: Article
Título de Revista/Publicación: Scientific Reports
Date: October 2019
ISSN: 2045-2322
Volume: 2019
Subjects:
Faculty: E.T.S.I. Industriales (UPM)
Department: Ingeniería Mecánica
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB) | Preview

Abstract

Several computational models, both continuum and discrete, allow for the simulation of collective cell behaviors in connection with challenges linked to disease modeling and understanding. Normally, discrete cell modelling employs quasi-infnite or boundary-less 2D lattices, hence modeling collective cell behaviors in Petri dish-like environments. The advent of lab- and organ-on-a-chip devices proves that the information obtained from 2D cell cultures, upon Petri dishes, difers importantly from the results obtained in more biomimetic micro-fuidic environments, made of interconnected chambers and channels. However, discrete cell modelling within lab- and organ-on-a-chip devices, to our knowledge, is not yet found in the literature, although it may prove useful for designing and optimizing these types of systems. Consequently, in this study we focus on the establishment of a direct connection between the computer-aided designs (CAD) of microfuidic systems, especially labs- and organs-onchips (and their multi-chamber and multi-channel structures), and the lattices for discrete cell modeling approaches aimed at the simulation of collective cell interactions, whose boundaries are defned directly from the CAD models. We illustrate the proposal using a quite straightforward cellular automata model, apply it to simulating cells with diferent growth rates, within a selected set of microsystem designs, and validate it by tuning the growth rates with the support of cell culture experiments and by checking the results with a real microfuidic system.

More information

Item ID: 63866
DC Identifier: http://oa.upm.es/63866/
OAI Identifier: oai:oa.upm.es:63866
DOI: 10.1038/s41598-019-51494-1
Official URL: https://www.nature.com/articles/s41598-019-51494-1
Deposited by: Memoria Investigacion
Deposited on: 26 Oct 2020 15:45
Last Modified: 26 Oct 2020 15:45
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM