Biofabrication strategies for creating microvascular complexity

Morss Clyne, Alisa and Swaminathan, Swathi and Díaz Lantada, Andrés (2019). Biofabrication strategies for creating microvascular complexity. "Biofabrication", v. 11 (n. 3); pp. 1-23. ISSN 1758-5090. https://doi.org/10.1088/1758-5090/ab0621.

Description

Title: Biofabrication strategies for creating microvascular complexity
Author/s:
  • Morss Clyne, Alisa
  • Swaminathan, Swathi
  • Díaz Lantada, Andrés
Item Type: Article
Título de Revista/Publicación: Biofabrication
Date: February 2019
ISSN: 1758-5090
Volume: 11
Subjects:
Freetext Keywords: biofabrication; vasculature; labs-on-chips; organs-on-chips; tissue engineering; additive manufacturing; computer-aided design and engineering
Faculty: E.T.S.I. Industriales (UPM)
Department: Ingeniería Mecánica
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Design and fabrication of effective biomimetic vasculatures constitutes a relevant and yet unsolved challenge, lying at the heart of tissue repair and regeneration strategies. Even if cell growth is achieved in 3D tissue scaffolds or advanced implants, tissue viability inevitably requires vascularization, as diffusion can only transport nutrients and eliminate debris within a few hundred microns. This engineered vasculature may need to mimic the intricate branching geometry of native microvasculature, referred to herein as vascular complexity, to efficiently deliver blood and recreate critical interactions between the vascular and perivascular cells as well as parenchymal tissues. This review first describes the importance of vascular complexity in labs- and organs-on-chips, the biomechanical and biochemical signals needed to create and maintain a complex vasculature, and the limitations of current 2D, 2.5D, and 3D culture systems in recreating vascular complexity. We then critically review available strategies for design and biofabrication of complex vasculatures in cell culture platforms, labs- and organs-on-chips, and tissue engineering scaffolds, highlighting their advantages and disadvantages. Finally, challenges and future directions are outlined with the hope of inspiring researchers to create the reliable, efficient and sustainable tools needed for design and biofabrication of complex vasculatures.

More information

Item ID: 63931
DC Identifier: http://oa.upm.es/63931/
OAI Identifier: oai:oa.upm.es:63931
DOI: 10.1088/1758-5090/ab0621
Official URL: https://iopscience.iop.org/article/10.1088/1758-5090/ab0621
Deposited by: Memoria Investigacion
Deposited on: 30 Oct 2020 16:38
Last Modified: 30 Oct 2020 16:38
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