Rehydration during exercise prevents the increase of homocysteine concentrations

Maroto Sánchez, Beatriz and López Torres, Olga and Valtueña Santamaría, Jara and Benito Peinado, Pedro José and Palacios Le Blé, Gonzalo and Enrique Diaz Martínez, Angel and González Iamuno, Domingo and Gonzalez Gross, Maria Marcela and Zinellu, Angelo and Carru, Ciriaco (2019). Rehydration during exercise prevents the increase of homocysteine concentrations. "Amino Acids", v. 51 (n. 2); pp. 193-204. ISSN 0939-4451. https://doi.org/10.1007/s00726-018-2655-y.

Description

Title: Rehydration during exercise prevents the increase of homocysteine concentrations
Author/s:
  • Maroto Sánchez, Beatriz
  • López Torres, Olga
  • Valtueña Santamaría, Jara
  • Benito Peinado, Pedro José
  • Palacios Le Blé, Gonzalo
  • Enrique Diaz Martínez, Angel
  • González Iamuno, Domingo
  • Gonzalez Gross, Maria Marcela
  • Zinellu, Angelo
  • Carru, Ciriaco
Item Type: Article
Título de Revista/Publicación: Amino Acids
Date: February 2019
ISSN: 0939-4451
Volume: 51
Subjects:
Freetext Keywords: Homocysteine; Hydration; Vitamins; Metabolism
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Salud y Rendimiento Humano
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase (MTHFR) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise (P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration.

More information

Item ID: 64115
DC Identifier: http://oa.upm.es/64115/
OAI Identifier: oai:oa.upm.es:64115
DOI: 10.1007/s00726-018-2655-y
Official URL: https://link.springer.com/journal/726/volumes-and-issues/51-2
Deposited by: Memoria Investigacion
Deposited on: 10 Nov 2020 11:30
Last Modified: 10 Nov 2020 11:30
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