CT2A cell viability modulated by electromagnetic fields at extremely low frequency under no thermal effects

García-Minguillán López, Olga and Prous, Raquel and Ramírez Castillejo, María del Carmen and Maestú Unturbe, Ceferino (2019). CT2A cell viability modulated by electromagnetic fields at extremely low frequency under no thermal effects. "International Journal of Molecular Sciences", v. 21 (n. 1); pp. 1-13. ISSN 1661-6596. https://doi.org/10.3390/ijms21010152.

Description

Title: CT2A cell viability modulated by electromagnetic fields at extremely low frequency under no thermal effects
Author/s:
  • García-Minguillán López, Olga
  • Prous, Raquel
  • Ramírez Castillejo, María del Carmen
  • Maestú Unturbe, Ceferino
Item Type: Article
Título de Revista/Publicación: International Journal of Molecular Sciences
Date: 24 December 2019
ISSN: 1661-6596
Volume: 21
Subjects:
Freetext Keywords: ELF-EMF; CT2A; cell viability; HSP90
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The effects produced by electromagnetic fields (EMFs) on human beings at extremely low frequencies (ELFs) have being investigated in the past years, across in vitro studies, using different cell lines. Nevertheless, the effects produced on cells are not clarified, and the cellular mechanisms and cell-signaling processes involved are still unknown. This situation has resulted in a division among the scientific community about the adequacy of the recommended level of exposure. In this sense, we consider that it is necessary to develop long-term exposure studies and check if the recommended levels of EMFs are under thermal effects. Hence, we exposed CT2A cells to different EMFs at different ELFs at short and long times. Our results showed frequency dependence in CT2A exposed during 24 h to a small EMF of 30 ?T equal to those originated by the Earth and frequency dependence after the exposure during seven days to an EMF of 100 µT at different ELFs. Particularly, our results showed a remarkable cell viability decrease of CT2A cells exposed to EMFs of 30 Hz. Nevertheless, after analyzing the thermal effects in terms of HSP90 expression, we did not find thermal damages related to the differences in cell viability, so other crucial cellular mechanism should be involved.

More information

Item ID: 64253
DC Identifier: http://oa.upm.es/64253/
OAI Identifier: oai:oa.upm.es:64253
DOI: 10.3390/ijms21010152
Official URL: https://www.mdpi.com/1422-0067/21/1/152
Deposited by: Memoria Investigacion
Deposited on: 07 Oct 2020 13:58
Last Modified: 07 Oct 2020 13:58
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