A thalamocortical pathway for fast rerouting of tactile information to occipital cortex in congenital blindness

Müller, Franziska and Niso Galán, Julia Guiomar and Samiee, Soheila and Ptito, Maurice and Baillet, Sylvain and Kupers, Ron (2019). A thalamocortical pathway for fast rerouting of tactile information to occipital cortex in congenital blindness. "Nature Communications", v. 10 (n. 5154); pp. 1-9. ISSN 2041-1723. https://doi.org/10.1038/s41467-019-13173-7.

Description

Title: A thalamocortical pathway for fast rerouting of tactile information to occipital cortex in congenital blindness
Author/s:
  • Müller, Franziska
  • Niso Galán, Julia Guiomar
  • Samiee, Soheila
  • Ptito, Maurice
  • Baillet, Sylvain
  • Kupers, Ron
Item Type: Article
Título de Revista/Publicación: Nature Communications
Date: 14 November 2019
ISSN: 2041-1723
Volume: 10
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

In congenitally blind individuals, the occipital cortex responds to various nonvisual inputs. Some animal studies raise the possibility that a subcortical pathway allows fast re-routing of tactile information to the occipital cortex, but this has not been shown in humans. Here we show using magnetoencephalography (MEG) that tactile stimulation produces occipital cortex activations, starting as early as 35 ms in congenitally blind individuals, but not in blindfolded sighted controls. Given our measured thalamic response latencies of 20 ms and a mean estimated lateral geniculate nucleus to primary visual cortex transfer time of 15 ms, we claim that this early occipital response is mediated by a direct thalamo-cortical pathway. We also observed stronger directed connectivity in the alpha band range from posterior thalamus to occipital cortex in congenitally blind participants. Our results strongly suggest the contribution of a fast thalamo-cortical pathway in the cross-modal activation of the occipital cortex in congenitally blind humans.

More information

Item ID: 64280
DC Identifier: http://oa.upm.es/64280/
OAI Identifier: oai:oa.upm.es:64280
DOI: 10.1038/s41467-019-13173-7
Official URL: https://www.nature.com/articles/s41467-019-13173-7
Deposited by: Memoria Investigacion
Deposited on: 10 Oct 2020 10:22
Last Modified: 10 Oct 2020 10:22
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