Effects of concurrent exercise training on muscle dysfunction and systemic oxidative stress in older people with COPD

Alcazar, Julián and Losa Reyna, José and Rodríguez López, Carlos and Navarro Cruz, Roberto and Alfaro Acha, Ana and Ara, Ignacio and García García, Francisco J. and Alegre, Luís M. and Guadalupe Grau, Amelia (2019). Effects of concurrent exercise training on muscle dysfunction and systemic oxidative stress in older people with COPD. "Scandinavian Journal of Medicine & Science in Sports", v. 29 (n. 10); pp. 1591-1603. ISSN 0905-7188. https://doi.org/10.1111/sms.13494.

Description

Title: Effects of concurrent exercise training on muscle dysfunction and systemic oxidative stress in older people with COPD
Author/s:
  • Alcazar, Julián
  • Losa Reyna, José
  • Rodríguez López, Carlos
  • Navarro Cruz, Roberto
  • Alfaro Acha, Ana
  • Ara, Ignacio
  • García García, Francisco J.
  • Alegre, Luís M.
  • Guadalupe Grau, Amelia
Item Type: Article
Título de Revista/Publicación: Scandinavian Journal of Medicine & Science in Sports
Date: October 2019
ISSN: 0905-7188
Volume: 29
Subjects:
Freetext Keywords: aerobic capacity; endurance training; lung disease; muscle architecture; power output; protein carbonyls; redox status; resistance training
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Salud y Rendimiento Humano
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Oxidative stress is associated with disease severity and limb muscle dysfunction in COPD. Our main goal was to assess the effects of exercise training on systemic oxidative stress and limb muscle dysfunction in older people with COPD. Twenty-nine outpatients with COPD (66-90 years) were randomly assigned to a 12-week exercise training (ET; high-intensity interval training (HIIT) plus power training) or a control (CT; usual care) group. We evaluated mid-thigh muscle cross-sectional area (CSA; computed tomography); vastus lateralis (VL) muscle thickness, pennation angle, and fascicle length (ultrasonography); peak VO2 uptake (VO2peak ) and work rate (Wpeak ) (incremental cardiopulmonary exercise test); rate of force development (RFD); maximal muscle power (Pmax ; force-velocity testing); systemic oxidative stress (plasma protein carbonylation); and physical performance and quality of life. ET subjects experienced changes in mid-thigh muscle CSA (+4%), VL muscle thickness (+11%) and pennation angle (+19%), VO2peak (+14%), Wpeak (+37%), RFD (+32% to 65%), Pmax (+38% to 51%), sit-to-stand time (-24%), and self-reported health status (+20%) (all P < 0.05). No changes were noted in the CT group (P > 0.05). Protein carbonylation decreased among ET subjects (-27%; P < 0.05), but not in the CT group (P > 0.05). Changes in protein carbonylation were associated with changes in muscle size and pennation angle (r = -0.44 to -0.57), exercise capacity (r = -0.46), muscle strength (r = -0.45), and sit-to-stand performance (r = 0.60) (all P < 0.05). The combination of HIIT and power training improved systemic oxidative stress and limb muscle dysfunction in older people with COPD. Changes in oxidative stress were associated with exercise-induced structural and functional adaptations.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainDEP2015‐69386‐RUnspecifiedUnspecifiedPrevención de la fragilidad mediante entrenamiento de fuerza a intensidades ligeras-moderadas vs. altas: efectos sobre el músculo, tendón, hueso y la calidad de vida
Government of SpainBES‐2016‐077199UnspecifiedUnspecifiedUnspecified
Government of SpainFPU014/05106UnspecifiedUnspecifiedUnspecified

More information

Item ID: 64292
DC Identifier: http://oa.upm.es/64292/
OAI Identifier: oai:oa.upm.es:64292
DOI: 10.1111/sms.13494
Official URL: https://onlinelibrary.wiley.com/doi/10.1111/sms.13494
Deposited by: Memoria Investigacion
Deposited on: 24 Nov 2020 08:33
Last Modified: 24 Nov 2020 08:33
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