Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players

Muñoz Moreno, Alejandro and López Samanes, Álvaro and Aguilar Navarro, Millán and Varillas Delgado, David and Rivilla García, Jesús and Moreno Pérez, Víctor and Coso, Juan del (2020). Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players. "Genes", v. 11 (n. 8); p. 933. ISSN 2073-4425. https://doi.org/10.3390/genes11080933.

Description

Title: Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players
Author/s:
  • Muñoz Moreno, Alejandro
  • López Samanes, Álvaro
  • Aguilar Navarro, Millán
  • Varillas Delgado, David
  • Rivilla García, Jesús
  • Moreno Pérez, Víctor
  • Coso, Juan del
Item Type: Article
Título de Revista/Publicación: Genes
Date: August 2020
ISSN: 2073-4425
Volume: 11
Subjects:
Freetext Keywords: ergogenic aids; genetics; polymorphism; team-sport athletes; sport performance
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Deportes
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Previous investigations have found that several genes may be associated with the interindividual variability to the ergogenic response to caffeine. The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (−163C  > A, rs762551; characterized such as “fast” (AA genotype) and “slow” caffeine metabolizers (C-carriers)) and ADORA2A (1976T  > C; rs5751876; characterized by “high” (TT genotype) or “low” sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players. Thirty-one professional handball players (sixteen men and fifteen women; daily caffeine intake = 60 ± 25 mg·d−1) ingested 3 mg·kg−1·body mass (bm) of caffeine or placebo 60 min before undergoing a battery of performance tests consisting of a countermovement jump (CMJ), a sprint test, an agility test, an isometric handgrip test, and several ball throws. Afterwards, the handball players performed a simulated handball match (2 × 20 min) while movements were recorded using inertial units. Saliva samples were analyzed to determine the genotype of each player for the −163C  > A polymorphism in the CYP1A2 gene (rs762551) and for the 1976T  > C polymorphism in the ADORA2A gene (rs5751876). In the CYP1A2, C-allele carriers (54.8%) were compared to AA homozygotes (45.2%). In the ADORA2A, C-allele carriers (80.6%) were compared to TT homozygotes (19.4%). There was only a genotype x treatment interaction for the ball throwing from 7 m (p = 0.037) indicating that the ergogenic effect of caffeine on this test was higher in CYP1A2 AA homozygotes than in C-allele carriers. In the remaining variables, there were no genotype x treatment interactions for CYP1A2 or for ADORA2A. As a whole group, caffeine increased CMJ height, performance in the sprint velocity test, and ball throwing velocity from 9 m (2.8–4.3%, p = 0.001–0.022, effect size = 0.17–0.31). Thus, pre-exercise caffeine supplementation at a dose of 3 mg·kg−1·bm can be considered as an ergogenic strategy to enhance some neuromuscular aspects of handball performance in professional handball players with low daily caffeine consumption. However, the ergogenic response to acute caffeine intake was not modulated by CYP1A2 or ADORA2A genotypes.

More information

Item ID: 64523
DC Identifier: http://oa.upm.es/64523/
OAI Identifier: oai:oa.upm.es:64523
DOI: 10.3390/genes11080933
Official URL: https://www.mdpi.com/2073-4425/11/8/933
Deposited by: Memoria Investigacion
Deposited on: 24 Nov 2020 10:03
Last Modified: 24 Nov 2020 10:03
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