Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise

Romero Parra, Nuria and Barba Moreno, Laura and Rael Delgado, Beatriz and Alfaro Magallanes, Víctor Manuel and Cupeiro Coto, Rocío and Díaz, Ángel E. and Calderón Montero, Francisco Javier and Peinado Lozano, Ana Belen (2020). Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise. "International Journal of Environmental Research and Public Health", v. 17 (n. 5); p. 1618. ISSN 1660-4601. https://doi.org/10.3390/ijerph17051618.

Description

Title: Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
Author/s:
  • Romero Parra, Nuria
  • Barba Moreno, Laura
  • Rael Delgado, Beatriz
  • Alfaro Magallanes, Víctor Manuel
  • Cupeiro Coto, Rocío
  • Díaz, Ángel E.
  • Calderón Montero, Francisco Javier
  • Peinado Lozano, Ana Belen
Item Type: Article
Título de Revista/Publicación: International Journal of Environmental Research and Public Health
Date: March 2020
ISSN: 1660-4601
Volume: 17
Subjects:
Freetext Keywords: sex hormones; creatine kinase; inflammation; female
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Salud y Rendimiento Humano
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The aim of this study was to evaluate whether the menstrual cycle and its underlying hormonal fluctuations affect muscle damage and inflammation in well-trained females following an eccentric exercise. Nineteen eumenorrheic women performed an eccentric squat-based exercise in the early follicular phase, late follicular phase and mid-luteal phase of their menstrual cycle. Sex hormones and blood markers of muscle damage and inflammation –creatine kinase, myoglobin, lactate dehydrogenase, interleukin-6, tumoral necrosis factor-α, and C reactive protein– were analyzed in each phase. No effect of menstrual cycle phase was observed (p > 0.05), while an interaction for interleukin-6 was shown (p = 0.047). Accordingly, a moderate effect size [0.68 (0.53)–0.84 (0.74)], indicated that interleukin-6 values 2 h post-trial (2.07 ± 1.26 pg/mL) were likely to be higher than baseline (1.59 ± 0.33 pg/mL), 24 h (1.50 ± 0.01 pg/mL) and 48 h (1.54 ± 0.13 pg/mL) in the mid-luteal phase. Blood markers of muscle damage and inflammation were not affected by the menstrual cycle in well-trained women. The eccentric exercise barely triggered muscle damage and hence, no inflammation was observed, possibly due to participants training status. The mid-luteal phase was the only phase reflecting a possible inflammatory response in terms of interleukin-6, although further factors than sex hormones seem to be responsible for this finding.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainDEP2016‐75387‐PIronFEMMEUnspecifiedInfluencia del ciclo menstrual en mujeres deportistas Metabolismo del hierro y daño muscular

More information

Item ID: 65349
DC Identifier: http://oa.upm.es/65349/
OAI Identifier: oai:oa.upm.es:65349
DOI: 10.3390/ijerph17051618
Official URL: https://www.mdpi.com/1660-4601/17/5/1618
Deposited by: Memoria Investigacion
Deposited on: 01 Dec 2020 08:51
Last Modified: 01 Dec 2020 08:51
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