Polyphenol-Functionalized Plant Viral-Derived Nanoparticles Exhibit Strong Antimicrobial and Antibiofilm Formation Activities

Velázquez Lam, Edith and Imperial Ródenas, Juan and Ponz Ascaso, Fernando (2020). Polyphenol-Functionalized Plant Viral-Derived Nanoparticles Exhibit Strong Antimicrobial and Antibiofilm Formation Activities. "ACS Applied Biomaterials", v. 3 (n. 4); pp. 2040-2047. ISSN 1944-8252. https://doi.org/10.1021/acsabm.9b01161.

Description

Title: Polyphenol-Functionalized Plant Viral-Derived Nanoparticles Exhibit Strong Antimicrobial and Antibiofilm Formation Activities
Author/s:
  • Velázquez Lam, Edith
  • Imperial Ródenas, Juan
  • Ponz Ascaso, Fernando
Item Type: Article
Título de Revista/Publicación: ACS Applied Biomaterials
Date: April 2020
ISSN: 1944-8252
Volume: 3
Subjects:
Freetext Keywords: viral nanoparticles; epigallocatechin gallate; polyphenols; tannins; antimicrobial activity; virus-derived particles
Faculty: Centro de Investigación en Biotecnología y Genómica de Plantas (CBGP) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Epigallocatechin gallate (EGCG) is a polyphenolic compound that shows a number of health-promoting effects, especially a broad antimicrobial activity. Virus-derived nanoparticles (VNPs) represent a promising drug carrier since they possess properties like biodegradability and their surface and interior are highly modifiable. Turnip mosaic virus (TuMV) VNPs offer an attractive number of conjugation sites on the external surface. EGCG-TuMV VNPs were synthesized by Mannich condensation, and their antimicrobial activities against the model bacteria Sarcina lutea, Pseudomonas aeruginosa, and Dickeya dadantii were tested. EGCG-TuMV VNPs did not only maintain TuMV structure but also showed an enhanced antimicrobial activity over that found with free EGCG for all of the bacteria tested. Biofilm formation by P. aeruginosa was also inhibited by EGCG-TuMV VNPs, contrary to free EGCG, which induced higher amounts of biofilm mass in a concentration-dependent manner. Taken together, our results open highly promising perspectives for the antimicrobial exploitation of EGCG-TuMV VNPs.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainAPCIN2016-00014-00-0NANOBIOAGRIUnspecifiedUnspecified
Government of SpainRTA2015-00017UnspecifiedUnspecifiedUna nueva forma de biocontrol de plagas y patógenos vegetales mediante la biología sintética de nanopartículas virales no infecciosas derivadas del Virus del mosaico del nabo

More information

Item ID: 65521
DC Identifier: http://oa.upm.es/65521/
OAI Identifier: oai:oa.upm.es:65521
DOI: 10.1021/acsabm.9b01161
Official URL: https://pubs.acs.org/doi/10.1021/acsabm.9b01161
Deposited by: Memoria Investigacion
Deposited on: 30 Nov 2020 07:58
Last Modified: 30 Nov 2020 07:58
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