Red de señalización del microambiente tumoral de células madre de Glioblastoma Multiforme condicionada por el sistema inmunológico y la proteína de autorrenovación celular PEDF

Luján Tirado, María (2020). Red de señalización del microambiente tumoral de células madre de Glioblastoma Multiforme condicionada por el sistema inmunológico y la proteína de autorrenovación celular PEDF. Proyecto Fin de Carrera / Trabajo Fin de Grado, E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM), Madrid.

Description

Title: Red de señalización del microambiente tumoral de células madre de Glioblastoma Multiforme condicionada por el sistema inmunológico y la proteína de autorrenovación celular PEDF
Author/s:
  • Luján Tirado, María
Contributor/s:
  • Ramírez Castillejo, María del Carmen
Item Type: Final Project
Degree: Grado en Biotecnología
Date: July 2020
Subjects:
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Glioblastoma Multiforme (GBM) is the deadliest form of brain cancer and one of the most aggressive tumours affecting the Central Nervous System. The accumulated evidence of the last decade has demonstrated that human cancer is a stem cell disease causing relapse in many patients. This may be caused by stem-like cells, called Cancer Stem Cells (CSCs). These cells undergo asymmetric division, which provides self-renewal capacity, ensures their maintenance, and makes them more chemoresistant. In this way, CSCs remain and invade distant niches, causing relapse. The interaction between CSCs and their tumour microenvironment through multiple factors, is key to understand its regulatory effect on tumour initiation, invasion, heterogeneity and therapeutic resistance influenced by CSCs. In the tumour niche of GBM, the immune system plays an important role, as CSCs take advantage of it by providing an immunosupressive environment, evading immune responses, and stimulating angiogenesis and metastasis. All of this contributes to the failure of current immunotherapy treatments. The actual chemotherapy treatment for GBM with the drug temozolomide (TMZ) also appears to be poorly effective, as CSCs eliminate its effect through several mechanisms. A promising solution for this issue is the Pigment Epithelium Derived Factor (PEDF). Some studies have described how the modified carboxyl terminal of this protein (CTE), in combination with TMZ, show a synergic antitumoral effect on GBM cell lines, increasing their response to treatments. Therefore, this project describes the tumour microenvironment of CSCs in GBM determined by the immune system and by PEDF. Its aim is to suggest future research lines that could result in the development of a more efficient therapy for GBM, consisting of a multiple strategy merging immunotherapy, TMZ and PEDF.

More information

Item ID: 66518
DC Identifier: http://oa.upm.es/66518/
OAI Identifier: oai:oa.upm.es:66518
Deposited by: Biblioteca ETSI Agrónomos
Deposited on: 24 Mar 2021 10:56
Last Modified: 24 Mar 2021 10:56
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