A minimalist design approach to antimicrobial agents based on a thionin template.

Vila Perello, Miguel and Tognon, Sabrina and Sánchez Vallet, Andrea and García Olmedo, Francisco and Molina Fernández, Antonio and Andreu, David (2006). A minimalist design approach to antimicrobial agents based on a thionin template.. "Journal of Medicinal Chemistry", v. 49 (n. 2); pp. 448-451. ISSN 0022-2623. https://doi.org/10.1021/jm050882i.

Description

Title: A minimalist design approach to antimicrobial agents based on a thionin template.
Author/s:
  • Vila Perello, Miguel
  • Tognon, Sabrina
  • Sánchez Vallet, Andrea
  • García Olmedo, Francisco
  • Molina Fernández, Antonio
  • Andreu, David
Item Type: Article
Título de Revista/Publicación: Journal of Medicinal Chemistry
Date: 2006
ISSN: 0022-2623
Volume: 49
Subjects:
Faculty: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Department: Biología Vegetal [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Numerous studies have been devoted to the stabilization of secondary structure elements to improve receptor−ligand recognition. We report a novel application of this principle to create new antimicrobial agents using the highly folded thionin from Pyrularia pubera as a template. Non-native disulfide bonds have been used to induce two short linear segments of the protein into an amphipathic helix. The resulting 13- and 9-residue peptides are significantly more active than their linear counterparts and have an activity similar to that of native thionin.

More information

Item ID: 7623
DC Identifier: http://oa.upm.es/7623/
OAI Identifier: oai:oa.upm.es:7623
DOI: 10.1021/jm050882i
Official URL: http://pubs.acs.org/doi/abs/10.1021/jm050882i
Deposited by: Memoria Investigacion
Deposited on: 20 Jun 2011 07:56
Last Modified: 22 Sep 2014 10:31
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