The K153 variant in the myostatin gene and sarcopenia at the end of the human lifespan

Gonzalez Freire, Marta; Rodríguez Romo, Gabriel; Santiago, Catalina; Bustamante Ara, Natalia; Yvert, Thomas; Gomez Gallego, Felix; Serra Rexach, Jose A.; Ruiz, Jonatan R. y Lucía Mulas, Alejandro (2010). The K153 variant in the myostatin gene and sarcopenia at the end of the human lifespan. "Age", v. 32 (n. 3); pp. 405-409. ISSN 0161-9152. https://doi.org/10.1007/s11357-010-9139-7.

Descripción

Título: The K153 variant in the myostatin gene and sarcopenia at the end of the human lifespan
Autor/es:
  • Gonzalez Freire, Marta
  • Rodríguez Romo, Gabriel
  • Santiago, Catalina
  • Bustamante Ara, Natalia
  • Yvert, Thomas
  • Gomez Gallego, Felix
  • Serra Rexach, Jose A.
  • Ruiz, Jonatan R.
  • Lucía Mulas, Alejandro
Tipo de Documento: Artículo
Título de Revista/Publicación: Age
Fecha: Septiembre 2010
Volumen: 32
Materias:
Palabras Clave Informales: Activities of daily living - GDF-8 - Muscle strength - Nonagenarians
Escuela: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Departamento: Deportes
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

We studied the A55T, E164K, I225T, K153R and P198A variants in the myostatin (GDF8) gene, muscle strength and mass, and physical function during daily living in 41 nonagenarians [33 women, age range, 90, 97]. No participant carried a mutant allele of the aforementioned variants, except three participants (all women), who carried the R allele of the K153R polymorphism, with one of them (woman aged 96 years) being homozygous. Overall, in KR women muscle phenotype values (1RM leg press and estimated muscle mass) were low-to-normal compared to the whole group (∼25th–50th percentile), and their functional capacity (Barthel and Tinetti tests) was normal. In the woman bearing the RR genotype, values of muscle mass and functional capacity were below the 25th percentile. She is the first RR Caucasian whose phenotype has been characterised specifically. In summary, heterozygosity for the GDF8 K153R polymorphism does not seem to exert a negative influence on the muscle phenotypes of women who are at the end of the human lifespan, yet homozygosity might do so. More research on larger cohorts of nonagenarians is needed to corroborate the present findings.

Más información

ID de Registro: 8483
Identificador DC: http://oa.upm.es/8483/
Identificador OAI: oai:oa.upm.es:8483
Identificador DOI: 10.1007/s11357-010-9139-7
URL Oficial: http://www.springerlink.com/content/600238nwk6664gh3/
Depositado por: Memoria Investigacion
Depositado el: 18 Ago 2011 09:50
Ultima Modificación: 20 Abr 2016 17:15
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