Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

Rodríguez Romo, Gabriel and Ruiz, Jonatan R. and Santiago, Catalina and Fiuza Luces, Carmen and Gonzalez Freire, Marta and Gomez Gallego, Felix and Moran, Maria and Lucía Mulas, Alejandro (2010). Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?. "European Journal of applied physiology", v. 110 (n. 6); pp. 1099-1106. ISSN 1439-6319. https://doi.org/10.1007/s00421-010-1608-2.

Description

Title: Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?
Author/s:
  • Rodríguez Romo, Gabriel
  • Ruiz, Jonatan R.
  • Santiago, Catalina
  • Fiuza Luces, Carmen
  • Gonzalez Freire, Marta
  • Gomez Gallego, Felix
  • Moran, Maria
  • Lucía Mulas, Alejandro
Item Type: Article
Título de Revista/Publicación: European Journal of applied physiology
Date: December 2010
ISSN: 1439-6319
Volume: 110
Subjects:
Freetext Keywords: Jump - Sprint - Genes - Genotype:phenotype association
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Deportes
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the α-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (≥90th of the sex-specific percentile). In summary, though the ACE I/D polymorphism is a strong candidate to modulate some exercise-related phenotypes or athletic performance status, this polymorphism, alone or in combination with the ACTN3 R577X polymorphism, does not seem to exert a major influence in the muscle ‘explosive’ power of young healthy adults, as assessed during multi-joint exercise tests.

More information

Item ID: 8494
DC Identifier: http://oa.upm.es/8494/
OAI Identifier: oai:oa.upm.es:8494
DOI: 10.1007/s00421-010-1608-2
Official URL: http://www.springerlink.com/content/6pql55268x462305/
Deposited by: Memoria Investigacion
Deposited on: 17 Aug 2011 11:31
Last Modified: 20 Apr 2016 17:15
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