Diffusion Tensor Imaging in Alzheimer's disease

Rios Lagos, Marcos and Periañez, J.A. and Hernández Tamames, J.A. and Frades, B. and Alvarez Linera, Juan and Saenz Lafourcade, C. and Lubrini, G. and Resler, G. and Frank, A. (2011). Diffusion Tensor Imaging in Alzheimer's disease. In: "The Global Alzheimer’s Research Summit", 22nd-23rd September, 2011, Madrid.


Title: Diffusion Tensor Imaging in Alzheimer's disease
  • Rios Lagos, Marcos
  • Periañez, J.A.
  • Hernández Tamames, J.A.
  • Frades, B.
  • Alvarez Linera, Juan
  • Saenz Lafourcade, C.
  • Lubrini, G.
  • Resler, G.
  • Frank, A.
Item Type: Presentation at Congress or Conference (Poster)
Event Title: The Global Alzheimer’s Research Summit
Event Dates: 22nd-23rd September, 2011
Event Location: Madrid
Title of Book: The Global Alzheimer’s Research Summit
Date: 2011
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Attentional control and Information processing speed are central concepts in cognitive psychology and neuropsychology. Functional neuroimaging and neuropsychological assessment have depicted theoretical models considering attention as a complex and non-unitary process. One of its component processes, Attentional set-shifting ability, is commonly assessed using the Trail Making Test (TMT). Performance in the TMT decreases with increasing age in adults, Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). Besides, speed of information processing (SIP) seems to modulate attentional performance. While neural correlates of attentional control have been widely studied, there are few evidences about the neural substrates of SIP in these groups of patients. Different authors have suggested that it could be a property of cerebral white matter, thus, deterioration of the white matter tracts that connect brain regions related to set-shifting may underlie the age-related, MCI and AD decrease in performance. The aim of this study was to study the anatomical dissociation of attentional and speed mechanisms. Diffusion tensor imaging (DTI) provides a unique insight into the cellular integrity of the brain, offering an in vivo view into the microarchitecture of cerebral white matter. At the same time, the study of ageing, characterized by white matter decline, provides the opportunity to study the anatomical substrates speeded or slowed information processing. We hypothesized that FA values would be inversely correlated with time to completion on Parts A and B of the TMT, but not the derived scores B/A and B-A.

More information

Item ID: 13587
DC Identifier: https://oa.upm.es/13587/
OAI Identifier: oai:oa.upm.es:13587
Deposited by: Memoria Investigacion
Deposited on: 25 Feb 2013 09:46
Last Modified: 21 Apr 2016 12:54
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