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Castro González, Carlos and Ledesma Carbayo, María Jesús and Peyrieras, Nadine and Santos Lleo, Andres de (2012). Assembling models of embryo development: Image analysis and the construction of digital atlases. "Birth Defects Research Part C", v. 96 (n. 2); pp. 109-120. ISSN 1542-9768. https://doi.org/10.1002/bdrc.21012.
Title: | Assembling models of embryo development: Image analysis and the construction of digital atlases |
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Author/s: |
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Item Type: | Article |
Título de Revista/Publicación: | Birth Defects Research Part C |
Date: | June 2012 |
ISSN: | 1542-9768 |
Volume: | 96 |
Subjects: | |
Faculty: | E.T.S.I. Telecomunicación (UPM) |
Department: | Ingeniería Electrónica |
Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
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Digital atlases of animal development provide a quantitative description of morphogenesis, opening the path toward processes modeling. Prototypic atlases offer a data integration framework where to gather information from cohorts of individuals with phenotypic variability. Relevant information for further theoretical reconstruction includes measurements in time and space for cell behaviors and gene expression. The latter as well as data integration in a prototypic model, rely on image processing strategies. Developing the tools to integrate and analyze biological multidimensional data are highly relevant for assessing chemical toxicity or performing drugs preclinical testing. This article surveys some of the most prominent efforts to assemble these prototypes, categorizes them according to salient criteria and discusses the key questions in the field and the future challenges toward the reconstruction of multiscale dynamics in model organisms.
Item ID: | 15215 |
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DC Identifier: | https://oa.upm.es/15215/ |
OAI Identifier: | oai:oa.upm.es:15215 |
DOI: | 10.1002/bdrc.21012 |
Official URL: | http://onlinelibrary.wiley.com/doi/10.1002/bdrc.21... |
Deposited by: | Memoria Investigacion |
Deposited on: | 10 Jun 2013 19:23 |
Last Modified: | 17 Jan 2017 12:23 |