Stoichiometric analysis of self-maintaining metabolisms

Montero, Francisco and Sanz Nuño, Juan Carlos and Meléndez-Hévia, Enrique and Olasagasti, Félix and Vázquez, Sara and Morán, Federico (2008). Stoichiometric analysis of self-maintaining metabolisms. "Journal of Theoretical Biology", v. 252 (n. 3); pp. 427-432. ISSN 0022-5193.


Title: Stoichiometric analysis of self-maintaining metabolisms
  • Montero, Francisco
  • Sanz Nuño, Juan Carlos
  • Meléndez-Hévia, Enrique
  • Olasagasti, Félix
  • Vázquez, Sara
  • Morán, Federico
Item Type: Article
Título de Revista/Publicación: Journal of Theoretical Biology
Date: June 2008
ISSN: 0022-5193
Volume: 252
Freetext Keywords: Stoichiometric analysis; Self-maintaining systems; Metabolic networks
Faculty: E.T.S.I. Montes (UPM)
Department: Matemática Aplicada a los Recursos Naturales [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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This paper presents an extension of stoichiometric analysis in systems where the catalytic compounds (enzymes) are also intermediates of the metabolic network (dual property), so they are produced and degraded by the reaction network itself. To take this property into account, we introduce the definition of enzyme-maintaining mode, a set of reactions that produces its own catalyst and can operate at stationary state. Moreover, an enzyme-maintaining mode is defined as elementary with respect to a given reaction if the removal of any of the remaining reactions causes the cessation of any steady state flux through this reference reaction. These concepts are applied to determine the network structure of a simple self-maintaining system.

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