Citation
Angulo Barrios, Carlos and Bañuls, María José and González-Pedro, Victoria and Gylfason, Kristinn B. and Sánchez, Benito and Griol Barres, Amadeu and Maquieira, A. and Sohlström, Hans and Holgado Bolaños, Miguel and Casquel del Campo, Rafael
(2008).
Label-free optical biosensing with slot-waveguides..
"Optics Letters", v. 33
(n. 7);
pp. 708-710.
ISSN 0146-9592.
Abstract
We demonstrate label-free molecule detection by using an integrated biosensor based on a Si3N4 /SiO2 slotwaveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2 nm/ _ng/mm2_ for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16 pg/mm2 for anti-BSA and BSA, respectively, limited by wavelength resolution
