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Ipharraguerre, Ignacio and Tedó, Gemma and Menoyo Luque, David and De Diego Cabero, Nuria and Holst, Jens J. and Nofrarías, Miquel and Mereu, Alessandro and Burrin, Douglas G. (2013). Bile Acids Induce Glucagon-Like Peptide 2 Secretion with Limited Effects on Intestinal Adaptation in Early Weaned Pigs. "Journal of Nutrition", v. 143 (n. 12); pp. 1899-1905. ISSN 0022-3166. https://doi.org/10.3945/jn.113.177865.
Title: | Bile Acids Induce Glucagon-Like Peptide 2 Secretion with Limited Effects on Intestinal Adaptation in Early Weaned Pigs |
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Author/s: |
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Item Type: | Article |
Título de Revista/Publicación: | Journal of Nutrition |
Date: | December 2013 |
ISSN: | 0022-3166 |
Volume: | 143 |
Subjects: | |
Faculty: | E.T.S.I. Agrónomos (UPM) [antigua denominación] |
Department: | Producción Animal [hasta 2014] |
Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
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Early weaning is a stressful event characterized by a transient period of intestinal atrophy that may be mediated by reduced secretion of glucagon-like peptide (GLP) 2. We tested whether enterally fed bile acids or plant sterols could increase nutrient-dependent GLP-2 secretion and improve intestinal adaptation in weanling pigs. During the first 6 d after weaning, piglets were intragastrically infused once daily with either deionized water -control-, chenodeoxycholic acid -CDC; 60mg/kg body weight-, or b-sitoesterol -BSE; 100 mg/kg body weight-. Infusing CDC increased plasma GLP-2 -P menor que 0.05- but did not affect plasma GLP-1 and feed intake. The intestinal expression of Glp2r -glucagon-like peptide 2 receptor-, Asbt -sodium-dependent bile acid transporter-, Fxr -farnesoid X receptor-, and Tgr5 -guanosine protein?coupled bile acid receptor- genes were not affected by CDC treatment. The intragastric administration of CDC did not alter the weight and length of the intestine, yet increased the activation of caspase-3 in ileal villi -P menor que 0.02- and the expression of Il6 -interleukin 6; P menor que 0.002- in the jejunum. In contrast, infusing BSE did not affect any of the variables that were measured. Our results show that the enteral administration of the bile acid CDC potentiates the nutrient-induced secretion of endogenous GLP-2 in early-weaned pigs. Bile acid?enhanced release of GLP-2, however, did not result in improved intestinal growth, morphology, or inflammation during the postweaning degenerative phase.
Item ID: | 26241 |
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DC Identifier: | https://oa.upm.es/26241/ |
OAI Identifier: | oai:oa.upm.es:26241 |
DOI: | 10.3945/jn.113.177865 |
Official URL: | http://jn.nutrition.org/content/143/12/1899.abstract?sid=261a953a-1602-45ff-9abf-13aa8ff40318 |
Deposited by: | Memoria Investigacion |
Deposited on: | 23 Jun 2014 13:37 |
Last Modified: | 22 Sep 2014 11:40 |