Functional hubs in mild cognitive impairment

Navas Santo-Tomas, Adrian and Papo, David and Boccaletti, Stefano and Pozo Guerrero, Francisco del and Bajo Breton, Ricardo and Maestú, Fernando and Gil, Pablo and Sendiña Nadal, Irene and Buldú, J.M. (2015). Functional hubs in mild cognitive impairment. "International Journal of Bifurcation and Chaos", v. 25 (n. 3); pp. 1-10. ISSN 0218-1274.


Title: Functional hubs in mild cognitive impairment
  • Navas Santo-Tomas, Adrian
  • Papo, David
  • Boccaletti, Stefano
  • Pozo Guerrero, Francisco del
  • Bajo Breton, Ricardo
  • Maestú, Fernando
  • Gil, Pablo
  • Sendiña Nadal, Irene
  • Buldú, J.M.
Item Type: Article
Título de Revista/Publicación: International Journal of Bifurcation and Chaos
Date: March 2015
ISSN: 0218-1274
Volume: 25
Freetext Keywords: Functional brain networks, synchronization likelihood, centrality, hub characterization, mild cognitive impairment
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures.

Funding Projects

Government of SpainFIS2009-07072UnspecifiedUnspecifiedUnspecified
Madrid Regional GovernmentS2009ESP-1691MODELICO-CMUnspecifiedUnspecified
Government of SpainPSI2012-38375-C03-01UnspecifiedUnspecifiedEntendiendo las quejas de memoria en el envejecimiento: una aproximación desde la genética, la neuropsicología y la conectividad anatomo-funcional
Madrid Regional GovernmentS2010/BMD-2460NEUROTEC-CMUnspecifiedUnspecified

More information

Item ID: 26570
DC Identifier:
OAI Identifier:
DOI: 10.1142/S0218127415500340
Official URL:
Deposited by: Memoria Investigacion
Deposited on: 13 Apr 2015 16:46
Last Modified: 30 Nov 2022 09:00
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