Functional hubs in mild cognitive impairment

Navas Santo-Tomas, Adrian, Papo, David, Boccaletti, Stefano, Pozo Guerrero, Francisco del ORCID: https://orcid.org/0000-0001-9919-9125, Bajo Breton, Ricardo, Maestú, Fernando, Gil, Pablo, Sendiña Nadal, Irene and Buldú, J.M. (2015). Functional hubs in mild cognitive impairment. "International Journal of Bifurcation and Chaos", v. 25 (n. 3); pp. 1-10. ISSN 0218-1274. https://doi.org/10.1142/S0218127415500340.

Description

Title: Functional hubs in mild cognitive impairment
Author/s:
  • Navas Santo-Tomas, Adrian
  • Papo, David
  • Boccaletti, Stefano
  • Pozo Guerrero, Francisco del https://orcid.org/0000-0001-9919-9125
  • Bajo Breton, Ricardo
  • Maestú, Fernando
  • Gil, Pablo
  • Sendiña Nadal, Irene
  • Buldú, J.M.
Item Type: Article
Título de Revista/Publicación: International Journal of Bifurcation and Chaos
Date: March 2015
ISSN: 0218-1274
Volume: 25
Subjects:
Freetext Keywords: Functional brain networks, synchronization likelihood, centrality, hub characterization, mild cognitive impairment
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures.

Funding Projects

Type
Code
Acronym
Leader
Title
Government of Spain
FIS2009-07072
Unspecified
Unspecified
Unspecified
Madrid Regional Government
S2009ESP-1691
MODELICO-CM
Unspecified
Unspecified
Government of Spain
PSI2012-38375-C03-01
Unspecified
Unspecified
Entendiendo las quejas de memoria en el envejecimiento: una aproximación desde la genética, la neuropsicología y la conectividad anatomo-funcional
Madrid Regional Government
S2010/BMD-2460
NEUROTEC-CM
Unspecified
Unspecified

More information

Item ID: 26570
DC Identifier: https://oa.upm.es/26570/
OAI Identifier: oai:oa.upm.es:26570
DOI: 10.1142/S0218127415500340
Official URL: http://www.worldscientific.com/doi/abs/10.1142/S02...
Deposited by: Memoria Investigacion
Deposited on: 13 Apr 2015 16:46
Last Modified: 30 Nov 2022 09:00
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