Ecological and genetic determinants of Pepino mosaic virus emergence

Moreno Pérez, Manuel Guillermo and Pagán Muñoz, Jesús Israel and Aragón Caballero, Liliana and Cáceres, Fátima and Fraile Pérez, Aurora and García Arenal, Fernando (2014). Ecological and genetic determinants of Pepino mosaic virus emergence. "Journal of Virology", v. 88 (n. 6); pp. 3359-3368. ISSN 0022-538X.


Title: Ecological and genetic determinants of Pepino mosaic virus emergence
  • Moreno Pérez, Manuel Guillermo
  • Pagán Muñoz, Jesús Israel
  • Aragón Caballero, Liliana
  • Cáceres, Fátima
  • Fraile Pérez, Aurora
  • García Arenal, Fernando
Item Type: Article
Título de Revista/Publicación: Journal of Virology
Date: March 2014
ISSN: 0022-538X
Volume: 88
Faculty: Centro de Investigación en Biotecnología y Genómica de Plantas (CBGP) (UPM)
Department: Biotecnologia [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Virus emergence is a complex phenomenon, which generally involves spread to a new host from a wild host, followed by adaptation to the new host. Although viruses account for the largest fraction of emerging crop pathogens, knowledge about their emergence is incomplete. We address here the question of whether Pepino mosaic virus (PepMV) emergence as a major tomato pathogen worldwide could have involved spread from wild to cultivated plant species and host adaptation. For this, we surveyed natural populations of wild tomatoes in southern Peru for PepMV infection. PepMV incidence, genetic variation, population structure, and accumulation in various hosts were analyzed. PepMV incidence in wild tomatoes was high, and a strain not yet reported in domestic tomato was characterized. This strain had a wide host range within the Solanaceae, multiplying efficiently in most assayed Solanum species and being adapted to wild tomato hosts. Conversely, PepMV isolates from tomato crops showed evidence of adaptation to domestic tomato, possibly traded against adaptation to wild tomatoes. Phylogenetic reconstructions indicated that the most probable ancestral sequence came from a wild Solanum species. A high incidence of PepMV in wild tomato relatives would favor virus spread to crops and its efficient multiplication in different Solanum species, including tomato, allowing its establishment as an epidemic pathogen. Later, adaptation to tomato, traded off against adaptation to other Solanum species, would isolate tomato populations from those in other hosts.

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Item ID: 34691
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OAI Identifier:
DOI: 10.1128/JVI.02980-13
Official URL:
Deposited by: Memoria Investigacion
Deposited on: 18 Apr 2015 10:43
Last Modified: 14 May 2019 11:59
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