MEG spectral analysis in subtypes of mild cognitive impairment

López García, María Eugenia, Cuesta Prieto, Pablo, Garcés López, Mª Pilar, Castellanos, Nazareth, Aurtenetxe, Sara, Bajo Breton, Ricardo, Marcos Dolado, Alberto, Delgado, M. L., Montejo, P., López Pantoja, J. L., Maestú Unturbe, Fernando and Fernández Lucas, Alberto (2014). MEG spectral analysis in subtypes of mild cognitive impairment. "AGE" ; pp. 1-18. ISSN 0161-9152.


Title: MEG spectral analysis in subtypes of mild cognitive impairment
  • López García, María Eugenia
  • Cuesta Prieto, Pablo
  • Garcés López, Mª Pilar
  • Castellanos, Nazareth
  • Aurtenetxe, Sara
  • Bajo Breton, Ricardo
  • Marcos Dolado, Alberto
  • Delgado, M. L.
  • Montejo, P.
  • López Pantoja, J. L.
  • Maestú Unturbe, Fernando
  • Fernández Lucas, Alberto
Item Type: Article
Título de Revista/Publicación: AGE
Date: 23 January 2014
ISSN: 0161-9152
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[thumbnail of INVE_MEM_2014_152521.pdf]
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (4MB) | Preview


Mild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic activity in amnestic MCI subtypes, a total of 105 subjects underwent an eyes-closed resting-state magnetoencephalographic recording: 36 healthy controls, 33 amnestic single domain MCIs (a-sd-MCI), and 36 amnestic multidomain MCIs (a-md-MCI). Relative power values were calculated and compared among groups. Subsequently, relative power values were correlated with neuropsychological tests scores and hippocampal volumes. Both MCI groups showed an increase in relative power in lower frequency bands (delta and theta frequency ranges) and a decrease in power values in higher frequency bands (alpha and beta frequency ranges), as compared with the control group. More importantly, clear differences emerged from the comparison between the two amnestic MCI subtypes. The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges. Such pattern correlated with the neuropsychological performance, indicating that the a-md-MCI subtype is associated not only with a "slowing" of the spectrum but also with a poorer cognitive status. These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease. Therefore, it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.

Funding Projects

Government of Spain
Government of Spain

More information

Item ID: 38811
DC Identifier:
OAI Identifier:
DOI: 10.1007/s11357-014-9624-5
Official URL:
Deposited by: Memoria Investigacion
Deposited on: 25 Apr 2017 17:05
Last Modified: 12 Jun 2019 08:07
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM