Solution-phase racemization in the presence of an enantiopure solid phase.

Abstract

Solution-phase racemization
drives the evolution of single chirality
in the solid phase by the "chiral amnesia"
process first described by Viedma.
The current investigations lay the basis
for a better understanding of the mechanism
of the solid-phase deracemization
by uncoupling the chemical rate
processes associated with the interconversion
of enantiomers in the solution
phase from the physical processes associated
with solution-solid phase transfer
via dissolution and reaccretion of
molecules onto crystals. In addition,
the enantiomer concentration profiles
presented in this work, together with
an analytical treatment of the racemization
process in the presence of excess
enantiopure solid, unequivocally reconfirm
the validity of the Meyerhoffer
double solubility rule for systems
under solution racemization conditions.