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Luengo Sánchez, Sergio and Bielza Lozoya, María Concepción and Benavides Piccione, Ruth and Fernaud Espinosa, Isabel and Felipe Oroquieta, Javier de and Larrañaga Múgica, Pedro María (2015). A univocal definition of the neuronal soma morphology using Gaussian mixture models. "Frontiers in Neuroanatomy", v. 9 ; pp. 1-11. ISSN 1662-5129. https://doi.org/10.3389/fnana.2015.00137.
Title: | A univocal definition of the neuronal soma morphology using Gaussian mixture models |
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Author/s: |
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Item Type: | Article |
Título de Revista/Publicación: | Frontiers in Neuroanatomy |
Date: | November 2015 |
ISSN: | 1662-5129 |
Volume: | 9 |
Subjects: | |
Freetext Keywords: | Three-dimensional soma reconstruction; Repair and segmentation; Morphology validation; Mesh comparison; Gaussian mixture model |
Faculty: | E.T.S. de Ingenieros Informáticos (UPM) |
Department: | Inteligencia Artificial |
Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
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The definition of the soma is fuzzy, as there is no clear line demarcating the soma of the labeled neurons and the origin of the dendrites and axon. Thus, the morphometric analysis of the neuronal soma is highly subjective. In this paper, we provide a mathematical definition and an automatic segmentation method to delimit the neuronal soma. We applied this method to the characterization of pyramidal cells, which are the most abundant neurons in the cerebral cortex. Since there are no benchmarks with which to compare the proposed procedure, we validated the goodness of this automatic segmentation method against manual segmentation by neuroanatomists to set up a framework for comparison. We concluded that there were no significant differences between automatically and manually segmented somata, i.e., the proposed procedure segments the neurons similarly to how a neuroanatomist does. It also provides univocal, justifiable and objective cutoffs. Thus, this study is a means of characterizing pyramidal neurons in order to objectively compare the morphometry of the somata of these neurons in different cortical areas and species.
Type | Code | Acronym | Leader | Title |
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Government of Spain | BFU2012-34963 | Unspecified | Agencia Estatal CSIF | Alteraciones neuroquímicas y microanatómicas de la corteza cerebral en la enfermedad de Alzheimer |
Government of Spain | CB06/05/0066 | Unspecified | Unspecified | Unspecified |
Government of Spain | TIN2013-41592-P | Unspecified | Universidad Politécnica de Madrid | Unspecified |
Madrid Regional Government | S2013/ICE-2845 | CASI - CAM | Universidad Politécnica de Madrid | Unspecified |
FP7 | 604102 | HBP | Unspecified | The Human Brain Project |
Item ID: | 41015 |
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DC Identifier: | https://oa.upm.es/41015/ |
OAI Identifier: | oai:oa.upm.es:41015 |
DOI: | 10.3389/fnana.2015.00137 |
Official URL: | http://journal.frontiersin.org/article/10.3389/fnana.2015.00137/full |
Deposited by: | Memoria Investigacion |
Deposited on: | 10 Jan 2017 10:10 |
Last Modified: | 06 Jun 2019 13:22 |