K-2P channels in plants and animals

Gonzalez, Wendy and Valdebenito, Braulio and Caballero, Julio and Riadi, Gonzalo and Riedelsberger, Janin and Martinez, G. and Ramirez, David and Zúñiga, Leandro and Sepulveda, Francisco V. and Dreyer, Ingo and Janta, Michael and Becker, Dirk (2015). K-2P channels in plants and animals. "Plugers Archiv-European Journal of physiology", v. 467 (n. 5); pp. 1091-1104. ISSN 0031-6768. https://doi.org/10.1007/s00424-014-1638-4.


Title: K-2P channels in plants and animals
  • Gonzalez, Wendy
  • Valdebenito, Braulio
  • Caballero, Julio
  • Riadi, Gonzalo
  • Riedelsberger, Janin
  • Martinez, G.
  • Ramirez, David
  • Zúñiga, Leandro
  • Sepulveda, Francisco V.
  • Dreyer, Ingo
  • Janta, Michael
  • Becker, Dirk
Item Type: Article
Título de Revista/Publicación: Plugers Archiv-European Journal of physiology
Date: May 2015
ISSN: 0031-6768
Volume: 467
Faculty: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Two-pore domain potassium (K2P) channels are membrane proteins widely identified in mammals, plants, and other organisms. A functional channel is a dimer with each subunit comprising two pore-forming loops and four transmembrane domains. The genome of the model plant Arabidopsis thaliana harbors five genes coding for K2P channels. Homologs of Arabidopsis K2P channels have been found in all higher plants sequenced so far. As with the K2P channels in mammals, plant K2P channels are targets of external and internal stimuli, which fine-tune the electrical properties of the membrane for specialized transport and/or signaling tasks. Plant K2P channels are modulated by signaling molecules such as intracellular H+ and calcium and physical factors like temperature and pressure. In this review, we ask the following: What are the similarities and differences between K2P channels in plants and animals in terms of their physiology? What is the nature of the last common ancestor (LCA) of these two groups of proteins? To answer these questions, we present physiological, structural, and phylogenetic evidence that discards the hypothesis proposing that the duplication and fusion that gave rise to the K2P channels occurred in a prokaryote LCA. Conversely, we argue that the K2P LCA was most likely a eukaryote organism. Consideration of plant and animal K2P channels in the same study is novel and likely to stimulate further exchange of ideas between students of these fields.

More information

Item ID: 41449
DC Identifier: https://oa.upm.es/41449/
OAI Identifier: oai:oa.upm.es:41449
DOI: 10.1007/s00424-014-1638-4
Official URL: http://link.springer.com/article/10.1007/s00424-014-1638-4
Deposited by: Memoria Investigacion
Deposited on: 07 Jul 2016 15:06
Last Modified: 07 Jul 2016 15:06
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