Full text
Preview |
PDF
- Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (683kB) | Preview |
Benito León, Julián, Louis, Elan D., Romero Muñoz, Juan Pablo, Hernández Tamames, J.A., Manzanedo Sáenz, Eva, Álvarez Linera, Juan, Bermejo Pareja, Félix, Posada Rodríguez, Ignacio Javier and Rocón de Lima, Eduardo (2015). Altered functional connectivity in essential tremor. "Medicine", v. 94 (n. 49); pp. 1-9. ISSN 0025-7974. https://doi.org/10.1097/MD.0000000000001936.
Title: | Altered functional connectivity in essential tremor |
---|---|
Author/s: |
|
Item Type: | Article |
Título de Revista/Publicación: | Medicine |
Date: | December 2015 |
ISSN: | 0025-7974 |
Volume: | 94 |
Subjects: | |
Faculty: | Centro de Automática y Robótica (CAR) UPM-CSIC |
Department: | Otro |
Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
Preview |
PDF
- Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (683kB) | Preview |
Essential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function. Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a ‘‘dualregression’’ technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected. Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability.Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability. ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms.
Item ID: | 43639 |
---|---|
DC Identifier: | https://oa.upm.es/43639/ |
OAI Identifier: | oai:oa.upm.es:43639 |
DOI: | 10.1097/MD.0000000000001936 |
Official URL: | https://insights.ovid.com/crossref?an=00005792-201... |
Deposited by: | Memoria Investigacion |
Deposited on: | 02 Apr 2017 08:45 |
Last Modified: | 10 Jun 2019 12:47 |