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Miguel Ramos, Mario de, Díaz Durán, Bárbara, Escolano Moyano, José Miguel, Barba Gea, Mariano ORCID: https://orcid.org/0000-0002-6819-4791, Mirea, Teona
ORCID: https://orcid.org/0000-0003-2324-4895, Olivares Roza, Jimena
ORCID: https://orcid.org/0000-0003-4396-4363, Clement Lorenzo, Marta
ORCID: https://orcid.org/0000-0003-4956-8206 and Iborra Grau, Enrique
ORCID: https://orcid.org/0000-0002-1385-1379
(2016).
Gravimetric biosensor based on a 1.3 GHz AlN shear-mode solidly mounted resonator.
"Sensors and actuators B-Chemical", v. 239
;
pp. 1282-1288.
ISSN 0925-4005.
https://doi.org/10.1016/j.snb.2016.09.079.
Title: | Gravimetric biosensor based on a 1.3 GHz AlN shear-mode solidly mounted resonator |
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Author/s: |
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Item Type: | Article |
Título de Revista/Publicación: | Sensors and actuators B-Chemical |
Date: | September 2016 |
ISSN: | 0925-4005 |
Volume: | 239 |
Subjects: | |
Freetext Keywords: | ravimetric biosensor, Shear mode AlN resonators, Surface functionalization, Sensor sensitivity |
Faculty: | E.T.S.I. Telecomunicación (UPM) |
Department: | Ingeniería Electrónica |
Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
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We investigate the performance of solidly mounted resonators based on Ir/tilted-AlN/Ir piezoelectric stacks as biosensors. These films are deposited by varying the pressure, the cathode power and the tem- perature of a two-step process based on depositing (00 • 2)-tilted AlN active layers over an (10 • 3)-oriented AlN seed layer. To minimize the influence of the temperature coefficient of frequency on the stability of the biosensor, we use insulating acoustic mirrors made of layers of SiO 2 and amorphous TaO x with non- /4 thicknesses, which enables to reduce the TCF to − 14 ppm/ ◦ C. The mass loading of the resonators with SiO 2 thin films results in a sensitivity of 1800 kHz/pg • cm 2 . Surface functionalization consists on the binding of silane groups on plasma oxidized SiO 2 surfaces. After a glutaraldehyde link, streptavidin is bonded to the surface to receive biotinylated receptors for several species. We test thrombin-binding aptamer (TBA29 against thrombin, and IgG antibody against immunoglobulin). The sensors response to species of different molecular weight like TBA-29 (9.75 kDa) or IgG antibody (150 kDa) is monitored. Finally, we assess the response of the biosensors to different thrombin concentrations (ranging from 4 nM to 270 nM) on surfaces functionalized with the TBA29 aptamer.
Item ID: | 50070 |
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DC Identifier: | https://oa.upm.es/50070/ |
OAI Identifier: | oai:oa.upm.es:50070 |
DOI: | 10.1016/j.snb.2016.09.079 |
Official URL: | https://www.sciencedirect.com/science/article/pii/... |
Deposited by: | Memoria Investigacion |
Deposited on: | 21 Apr 2018 08:13 |
Last Modified: | 25 Mar 2019 15:50 |