How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid

López Hernández, Ana ORCID: https://orcid.org/0000-0002-4415-1826, Casquel Del Campo, Rafael ORCID: https://orcid.org/0000-0003-2433-9159, Holgado Bolaños, Miguel ORCID: https://orcid.org/0000-0001-9299-1371, Cornago, Iñaki, Fernández, Fátima, Ciaurriz, Paula, Sanza Gutiérrez, Francisco Javier, Santamaría Fernández, Beatriz ORCID: https://orcid.org/0000-0003-3714-7922, Maigler, M. Victoria, Quintero Moreno, Sergio Andrés ORCID: https://orcid.org/0000-0002-4545-7819 and Laguna Heras, Maria Fe ORCID: https://orcid.org/0000-0002-1580-4509 (2018). How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid. "Sensors and Actuators B: Chemical", v. 259 ; pp. 956-962. ISSN 0925-4005. https://doi.org/10.1016/j.snb.2017.11.029.

Description

Title: How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid
Author/s:
Item Type: Article
Título de Revista/Publicación: Sensors and Actuators B: Chemical
Date: 15 April 2018
ISSN: 0925-4005
Volume: 259
Subjects:
Freetext Keywords: Biosensing enhance between dry/wet conditions; Optical biosensor; Resonant nanopillars; In-situ diagnosis; Vertical optical interrogation; Label-free
Faculty: E.T.S.I. Industriales (UPM)
Department: Física Aplicada e Ingeniería de Materiales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

In this work we demonstrate the advantage of performing the biosensing process of a refractive indexoptical biosensor under dry conditions, in comparison with the biosensing structure immersed in fluid.We developed a biosensing experiment over a specific transducer based on resonant nanopillars (R-NPs)arrays. The optical interrogation to monitor the recognition events was firstly performed with the R-NPsin dry, only in contact with the air, and secondly with the R-NPs immersed in water. We observed asignificant enhance in the sensitivity of the biosensing curve response for the R-NPs in dry conditions,leading an improvement of the Limit of Detection (LoD) in more than one order of magnitude. These resultsare also in good correlation with 3D-Finite difference time domain simulations carried out for both fluidconditions. According to this result, any interferometric optical bio-transducer for in-situ diagnosis willimprove the sensitivity in case it can operate in dry conditions. Moreover, measuring in simple drops ofbiological samples, in dry conditions, will be a relevant issue for Point of Care Devices

Funding Projects

Type
Code
Acronym
Leader
Title
FP7
614057
Enviguard
Unspecified
OCEAN 2013.1 - Biosensors for real time monitoring of biohazard and man made chemical contaminants in the marine environment
Government of Spain
TEC2012-31145
PLATON
Unspecified
BIOCHIP KITS BASADOS EN CELDAS BIOFOTONICAS Y PLATAFORMAS AVANZADAS DE INTERROGACION OPTICA
Government of Spain
RTC-2015-3273-1
ATAPOC
Unspecified
Desarrollo y validación clínica de un dispositivo para el diagnóstico y seguimiento de las alergias y tolerancias alimentarias

More information

Item ID: 50264
DC Identifier: https://oa.upm.es/50264/
OAI Identifier: oai:oa.upm.es:50264
DOI: 10.1016/j.snb.2017.11.029
Official URL: https://www.sciencedirect.com/science/article/pii/...
Deposited by: Memoria Investigacion
Deposited on: 13 Jun 2018 16:55
Last Modified: 16 Apr 2020 22:30
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