Full text
Preview |
PDF
- Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (460kB) | Preview |
López Hernández, Ana ORCID: https://orcid.org/0000-0002-4415-1826, Casquel Del Campo, Rafael
ORCID: https://orcid.org/0000-0003-2433-9159, Holgado Bolaños, Miguel
ORCID: https://orcid.org/0000-0001-9299-1371, Cornago, Iñaki, Fernández, Fátima, Ciaurriz, Paula, Sanza Gutiérrez, Francisco Javier, Santamaría Fernández, Beatriz
ORCID: https://orcid.org/0000-0003-3714-7922, Maigler, M. Victoria, Quintero Moreno, Sergio Andrés
ORCID: https://orcid.org/0000-0002-4545-7819 and Laguna Heras, Maria Fe
ORCID: https://orcid.org/0000-0002-1580-4509
(2018).
How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid.
"Sensors and Actuators B: Chemical", v. 259
;
pp. 956-962.
ISSN 0925-4005.
https://doi.org/10.1016/j.snb.2017.11.029.
Title: | How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid |
---|---|
Author/s: |
|
Item Type: | Article |
Título de Revista/Publicación: | Sensors and Actuators B: Chemical |
Date: | 15 April 2018 |
ISSN: | 0925-4005 |
Volume: | 259 |
Subjects: | |
Freetext Keywords: | Biosensing enhance between dry/wet conditions; Optical biosensor; Resonant nanopillars; In-situ diagnosis; Vertical optical interrogation; Label-free |
Faculty: | E.T.S.I. Industriales (UPM) |
Department: | Física Aplicada e Ingeniería de Materiales |
Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
Preview |
PDF
- Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (460kB) | Preview |
In this work we demonstrate the advantage of performing the biosensing process of a refractive indexoptical biosensor under dry conditions, in comparison with the biosensing structure immersed in fluid.We developed a biosensing experiment over a specific transducer based on resonant nanopillars (R-NPs)arrays. The optical interrogation to monitor the recognition events was firstly performed with the R-NPsin dry, only in contact with the air, and secondly with the R-NPs immersed in water. We observed asignificant enhance in the sensitivity of the biosensing curve response for the R-NPs in dry conditions,leading an improvement of the Limit of Detection (LoD) in more than one order of magnitude. These resultsare also in good correlation with 3D-Finite difference time domain simulations carried out for both fluidconditions. According to this result, any interferometric optical bio-transducer for in-situ diagnosis willimprove the sensitivity in case it can operate in dry conditions. Moreover, measuring in simple drops ofbiological samples, in dry conditions, will be a relevant issue for Point of Care Devices
Item ID: | 50264 |
---|---|
DC Identifier: | https://oa.upm.es/50264/ |
OAI Identifier: | oai:oa.upm.es:50264 |
DOI: | 10.1016/j.snb.2017.11.029 |
Official URL: | https://www.sciencedirect.com/science/article/pii/... |
Deposited by: | Memoria Investigacion |
Deposited on: | 13 Jun 2018 16:55 |
Last Modified: | 16 Apr 2020 22:30 |