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Shen, Yajing and Cheng, Yu and Uyeda, Taro Q. P. and Plaza Baonza, Gustavo Ramón (2017). Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate. "Annals of Biomedical Engineering", v. 45 (n. 10); pp. 2475-2486. ISSN 1573-9686. https://doi.org/10.1007/s10439-017-1884-7.
Title: | Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate |
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Author/s: |
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Item Type: | Article |
Título de Revista/Publicación: | Annals of Biomedical Engineering |
Date: | 25 July 2017 |
ISSN: | 1573-9686 |
Volume: | 45 |
Subjects: | |
Freetext Keywords: | Mechanotransduction, Signaling Cascade, Cytoskeleton, Magnetic Nanoparticles, Rotating Magnetic Field, Functionalization, Organelle Targeting, Localized Stimulation, Cell Differentiation |
Faculty: | E.T.S.I. Caminos, Canales y Puertos (UPM) |
Department: | Ciencia de los Materiales |
Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
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The use of magnetic nanoparticles (MNPs) is a promising technique for future advances in biomedical applications. This idea is supported by the availability of MNPs that can target specific cell components, the variety of shapes of MNPs and the possibility of finely controlling the applied magnetic forces. To examine this opportunity, here we review the current developments in the use of MNPs to mechanically stimulate cells and, specifically, the cell mechanotransduction systems. We analyze the cell components that may act as mechanosensors and their effect on cell fate and we focus on the promising possibilities of controlling stem-cell differentiation, inducing cancer-cell death and treating nervous-system diseases.
Type | Code | Acronym | Leader | Title |
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Government of Spain | MAT2016-76847-R | MINECO | Unspecified | Deformabilidad de linfocitos T como biomarcador mecánico de inmunosenescencia y desarrollo de tecnología para su aplicación clínica |
Item ID: | 52686 |
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DC Identifier: | https://oa.upm.es/52686/ |
OAI Identifier: | oai:oa.upm.es:52686 |
DOI: | 10.1007/s10439-017-1884-7 |
Official URL: | https://link.springer.com/article/10.1007%2Fs10439-017-1884-7 |
Deposited by: | Memoria Investigacion |
Deposited on: | 19 Oct 2018 11:02 |
Last Modified: | 19 Oct 2018 11:02 |