Quantitative analysis of early-phase 18F-flutemetamol PET brain images

Dghoughi, Walid and Seiffert, Alexander Peter and Gómez Grande, Adolfo and Villarejo Galende, Alberto and Bueno Zamora, Héctor J. and Gómez Aguilera, Enrique J. and Sánchez González, Patricia (2019). Quantitative analysis of early-phase 18F-flutemetamol PET brain images. In: "XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, CASEIB 2019", 27/11/2019 - 29/11/2019, Santander, España. ISBN 978-84-09-16707-4. pp. 183-186.

Description

Title: Quantitative analysis of early-phase 18F-flutemetamol PET brain images
Author/s:
  • Dghoughi, Walid
  • Seiffert, Alexander Peter
  • Gómez Grande, Adolfo
  • Villarejo Galende, Alberto
  • Bueno Zamora, Héctor J.
  • Gómez Aguilera, Enrique J.
  • Sánchez González, Patricia
Item Type: Presentation at Congress or Conference (Article)
Event Title: XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, CASEIB 2019
Event Dates: 27/11/2019 - 29/11/2019
Event Location: Santander, España
Title of Book: Actas del XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, CASEIB 2019
Date: 2019
ISBN: 978-84-09-16707-4
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

PET imaging techniques can be used to visualise the two major biomarkers of Alzheimer’s disease(AD).A series of radiotracers bind to amyloid-beta (Aβ) plaques in the brain while cerebral metabolism is assessed on18F-fluorodeoxyglucose (FDG)PET images.It is demonstrated that acquiring a PET image up to 10 minutes after the injection of anAβ-binding tracer yieldsimages that resemble PET images acquired with FDG. Therefore, these early-phase PET-amyloid images are suggested to be a surrogate to PET-FDG images and offer information about the cerebral perfusion, which is closely linked to the cerebral metabolism.In this work, early-phase PET images acquired with 18F-flutemetamol (FMM)are analysed and the correlation with FDG images is quantitatively assessed. Moreover, the results are compared to studies that used two different Aβ-binding tracers, namely 18F-florbetapir (FBP) and 18F-florbetaben (FBB).The Pearson’s correlation coefficient(r)is used to analyse how the standard uptake value ratios (SUVR)of different regions of interest of early-phase FMM and FDG images are related.An average correlation(± standard deviation)of r = 0.76 ±0.07 is obtained.ROI-based analysis showed that the highest correlation between both images is present in the right temporal lobe (r = 0.85).These values are comparable to the two selected studies that are based on early-phase FBP and FBB images. Therefore, the results suggest that early-phase PET-FMM acquisitions offer similar information to PET-FDG images.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainFPU16/06487UnspecifiedUnspecifiedBeca de Formación de Profesorado Universitario

More information

Item ID: 63221
DC Identifier: https://oa.upm.es/63221/
OAI Identifier: oai:oa.upm.es:63221
Official URL: http://caseib.es/2019/
Deposited by: Memoria Investigacion
Deposited on: 04 Nov 2020 15:22
Last Modified: 04 Nov 2020 15:22
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