Optical imaging technologies and opto-biomechanical models for diagnostics and customized treatment in ophthalmology

Hoz Durán, Andrés de la (2020). Optical imaging technologies and opto-biomechanical models for diagnostics and customized treatment in ophthalmology. Thesis (Doctoral), E.T.S.I. Telecomunicación (UPM). https://doi.org/10.20868/UPM.thesis.66901.

Description

Title: Optical imaging technologies and opto-biomechanical models for diagnostics and customized treatment in ophthalmology
Author/s:
  • Hoz Durán, Andrés de la
Contributor/s:
  • Marcos Celestino, Susana
  • Rojo Pérez, Francisco Javier
Item Type: Thesis (Doctoral)
Read date: 2020
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

This thesis presents an experimental work in which optical technologies and numerical and mechanical models are used to develop methods for diagnostics (through analysis of the mechanical properties of tissues) and treatment (through the development of techniques and devices) in ophthalmology, specifically on tissues of the anterior segment of the eye: the cornea and the crystalline lens. Numerical models of crystalline lenses and corneas were developed. Experimental measurements of lenses and corneas under loading were taken, and an inverse modeling approach was used to combine the experimental data and numerical models to retrieve the mechanical parameters of the tissues. The results were validated in order to assess their reliability and evaluate the use of the models in diagnosing ocular conditions. Numerical models were used to develop an accommodating intraocular lens. A custom experimental system for the evaluation of optical and geometric changes upon the lens under quantifiable loading were developed and validated. A prototype of the accommodating lens concept was manufactured and evaluated in the system, and the results were validated by numerical simulations. Finally, the viability of a light-based technology, Rose Bengal photobonding, was evaluated for bonding of corneal tissue with silk fibroin films. Extensiometry and inflation measurements were done in order to evaluate the strength of the bonding force between tissue and silk. ----------RESUMEN---------- Esta tesis presenta un trabajo de investigación en el que se emplearon tecnologías ópticas y mecánicas, así como modelos numéricos para desarrollar métodos de diagnóstico (mediante el análisis de las propiedades mecánicas de tejidos) y tratamiento (mediante el desarrollo de técnicas y dispositivos) en oftalmología, específicamente en tejidos del segmento anterior: la córnea y el cristalino. Se desarrollaron modelos numéricos del cristalino y la córnea. Se hizo una serie de medidas experimentales de cristalinos y córneas bajo diferentes condiciones de carga. Mediante la técnica de modelado inverso se combinaron los datos experimentales y los modelos numéricos para obtener las propiedades mecánicas inherentes de los tejidos. Los resultados fueron validados y se evaluó su fiabilidad. Se desarrollaron modelos numéricos para el diseño de una lente acomodativa. Se desarrolló y validó un sistema de evaluación experimental de los cambios de propiedades ópticas y mecánicas en acomodación. Se fabricó un prototipo de lente acomodativa que fue evaluado en este sistema, y los resultados se validaron mediante la plataforma de simulación numérica. Se ha estudiado la viabilidad de una técnica óptica, fotoenlace químico con Rosa de Bengala, para el uso de películas de fibroína de seda sobre el tejido corneal. Se hicieron ensayos de tracción y de inflado, para evaluar la resistencia de la unión entre tejido y seda.

More information

Item ID: 66901
DC Identifier: https://oa.upm.es/66901/
OAI Identifier: oai:oa.upm.es:66901
DOI: 10.20868/UPM.thesis.66901
Deposited by: Archivo Digital UPM 2
Deposited on: 29 Apr 2021 06:20
Last Modified: 28 Oct 2021 22:30
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