Electrocardiographic fragmented activity (I): physiological meaning of multivariate signal decompositions

Melgarejo Meseguer, Francisco Manuel and Gimeno Blanes, Francisco Javier and Salar Alcáraz, María Eladia and Gimeno Blanes, Juan Ramón and Martínez Sánchez, Juan and García Alberola, Arcadi and Rojo Álvarez, José Luis (2019). Electrocardiographic fragmented activity (I): physiological meaning of multivariate signal decompositions. "Applied Sciences", v. 9 (n. 17); pp. 3566-3598. ISSN 2076-3417. https://doi.org/10.3390/app9173566.


Title: Electrocardiographic fragmented activity (I): physiological meaning of multivariate signal decompositions
  • Melgarejo Meseguer, Francisco Manuel
  • Gimeno Blanes, Francisco Javier
  • Salar Alcáraz, María Eladia
  • Gimeno Blanes, Juan Ramón
  • Martínez Sánchez, Juan
  • García Alberola, Arcadi
  • Rojo Álvarez, José Luis
Item Type: Article
Título de Revista/Publicación: Applied Sciences
Date: 2019
ISSN: 2076-3417
Volume: 9
Freetext Keywords: ECG, Fragmentation analysis, Multivariate techniques, ICA, PCA, Fragmentation detection
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (2MB) | Preview


Recent research has proven the existence of statistical relation among fragmented QRS and several highly prevalence diseases, such as cardiac sarcoidosis, acute coronary syndrome, arrythmogenic cardiomyopathies, Brugada syndrome, and hypertrophic cardiomyopathy. One out of five hundred people suffer from hypertrophic cardiomyopathies. The relation among the fragmentation and arrhythmias drives the objective of this work, which is to propose a valid method for QRS fragmentation detection. With that aim, we followed a two-stage approach. First, we identified the features that better characterize the fragmentation by analyzing the physiological interpretation of multivariate approaches, such as principal component analysis (PCA) and independent component analysis (ICA). Second, we created an invariant transformation method for the multilead electrocardiogram (ECG), by scrutinizing the statistical distributions of the PCA eigenvectors and of the ICA transformation arrays, in order to anchor the desired elements in the suitable leads in the feature space. A complete database was compounded incorporating real fragmented ECGs, surrogate registers by synthetically adding fragmented activity to real non-fragmented ECG registers, and standard clean ECGs. Results showed that the creation of beat templates together with the application of PCA over eight independent leads achieves 0.995 fragmentation enhancement ratio and 0.07 dispersion coefficient. In the case of ICA over twelve leads, the results were 0.995 fragmentation enhancement ratio and 0.70 dispersion coefficient. We conclude that the algorithm presented in this work constructs a new paradigm, by creating a systematic and powerful tool for clinical anamnesis and evaluation based on multilead ECG. This approach consistently consolidates the inconspicuous elements present in multiple leads onto designated variables in the output space, hence offering additional and valid visual and non-visual information to standard clinical review, and opening the door to a more accurate automatic detection and statistically valid systematic approach for a wide number of applications. In this direction and within the companion paper, further developments are presented applying this technique to fragmentation detection.

Funding Projects

Government of SpainTEC2016-75161-C2-1-RUnspecifiedUniversidad Rey Juan CarlosInvestigación traslacional y transferencia de un nuevo sistema de electrofisiología cardiaca no inavasiva de alta resolución
Government of SpainTEC2016-75161-C2-2-RUnspecifiedUnspecifiedSistema automático y nueva algoritmia de procesamiento de señales cardiacas para monitorización prolongada mediante aprendizaje estadístico desde la práctica médica habitual
Government of SpainTEC2016-81900-REDTKERMESUniversidad de ValenciaAvances en métodos núcleo para datos estructurados

More information

Item ID: 67116
DC Identifier: https://oa.upm.es/67116/
OAI Identifier: oai:oa.upm.es:67116
DOI: 10.3390/app9173566
Official URL: https://www.mdpi.com/2076-3417/9/17/3566
Deposited by: Memoria Investigacion
Deposited on: 18 May 2021 07:05
Last Modified: 18 May 2021 07:05
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM