Perspectivas biotecnológicas en el diagnóstico y la terapia de la enfermedad de Alzheimer

Hernández Suárez, Ana (2021). Perspectivas biotecnológicas en el diagnóstico y la terapia de la enfermedad de Alzheimer. Proyecto Fin de Carrera / Trabajo Fin de Grado, E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM), Madrid.

Description

Title: Perspectivas biotecnológicas en el diagnóstico y la terapia de la enfermedad de Alzheimer
Author/s:
  • Hernández Suárez, Ana
Contributor/s:
  • López Torrejón, Gema
Item Type: Final Project
Degree: Grado en Biotecnología
Date: February 2021
Subjects:
Freetext Keywords: Alzheimer’s disease, amyloid, tau, biomarkers, diagnosis, treatment
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Alzheimer’s disease (AD), the most common form of dementia in the elderly, is a growing global health concern with huge implications for individuals and society. AD is still defined by the combined presence of amyloid and tau. However, researchers are gradually moving away from the simple assumption of linear causality as proposed in the original amyloid hypothesis. Diagnosis has made significant progress in recent years: amyloid 42 and tau proteins have been established as core cerebrospinal biomarkers and novel candidate biomarkers have been identified, including amyloid oligomers, synaptic markers and neuroimaging technics. In the search for understanding the pathological mechanisms and keys to the treatment of Alzheimer’s disease, research is increasingly moving towards the earliest stage of the disease. Nowadays, several approved drugs ameliorate some of the symptoms of Alzheimer’s disease, although no current intervention can modify its underlying mechanisms. In this review we discuss the main developments in Alzheimer’s research and we highlight the fact that further research is required.

More information

Item ID: 68946
DC Identifier: https://oa.upm.es/68946/
OAI Identifier: oai:oa.upm.es:68946
Deposited by: Biblioteca ETSI Agrónomos
Deposited on: 28 Oct 2021 12:42
Last Modified: 28 Dec 2021 23:30
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