Consecuencias reproductivas y heredables de la exposición paterna a alcohol en ratones

Puyol Colinas, Carolina (2021). Consecuencias reproductivas y heredables de la exposición paterna a alcohol en ratones. Proyecto Fin de Carrera / Trabajo Fin de Grado, E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM), Madrid.

Description

Title: Consecuencias reproductivas y heredables de la exposición paterna a alcohol en ratones
Author/s:
  • Puyol Colinas, Carolina
Contributor/s:
  • Gutiérrez Adán, Alfonso
  • García Rebollar, Pilar
Item Type: Final Project
Degree: Grado en Biotecnología
Date: July 2021
Subjects:
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Producción Agraria
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Nowadays, Binge Drinking (BD) has become a major health problem and there is a critical need to understand the effects of this alcohol consumption pattern and its inheritance. BD is characterized by chronic-intermittent consumption of large quantities of alcohol in short periods of time. Although clinical research has provided information regarding the risks and consequences of this consumption pattern, human studies cannot thoroughly examine all the effects of BD due to ethical limitations. As a result, animal models can be useful to understand all the consequences of BD. The main objective of the present study is to create an animal model of alcohol “binge drinking” and therefore being able to study reproductive and neurobehavioral consequences of this consumption pattern in male mice. In addition, it also focuses on analyzing the transmitted phenotypes by the paternal germline to the offspring, as most studies that examine intergenerational effects of alcohol have focused on the maternal alcohol abuse during pregnancy. The most outstanding results of the investigation show that male mice subjected to a chronic and intermittent alcohol protocol, characteristic of BD, have lower short-term memory than control mice. In addition, this phenotype is inherited by offsprings and therefore could be considered a multigenerational phenotype. It also causes differences in mice depressive behavior. On the other hand, embryos obtained from alcohol-treated male sperm have a reduced Gapdh (glyceraldehyde-3-phosphate dehydrogenase) gene expression in the blastocyst state.

More information

Item ID: 69391
DC Identifier: https://oa.upm.es/69391/
OAI Identifier: oai:oa.upm.es:69391
Deposited by: Biblioteca ETSI Agrónomos
Deposited on: 10 Jan 2022 14:16
Last Modified: 10 Jan 2022 14:16
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