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A minimalist design approach to antimicrobial agents based on a thionin template.
Citation
Vila Perello, Miguel and Tognon, Sabrina and Sánchez Vallet, Andrea and García Olmedo, Francisco and Molina Fernández, Antonio and Andreu, David (2006). A minimalist design approach to antimicrobial agents based on a thionin template.. "Journal of Medicinal Chemistry", v. 49 (n. 2); pp. 448-451. ISSN 0022-2623. https://doi.org/10.1021/jm050882i.
Description
| Title: | A minimalist design approach to antimicrobial agents based on a thionin template. |
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| Author/s: |
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| Item Type: | Article |
| Título de Revista/Publicación: | Journal of Medicinal Chemistry |
| Date: | 2006 |
| ISSN: | 0022-2623 |
| Volume: | 49 |
| Subjects: | |
| Faculty: | E.T.S.I. Agrónomos (UPM) [antigua denominación] |
| Department: | Biología Vegetal [hasta 2014] |
| Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
Abstract
Numerous studies have been devoted to the stabilization of secondary structure elements to improve receptor−ligand recognition. We report a novel application of this principle to create new antimicrobial agents using the highly folded thionin from Pyrularia pubera as a template. Non-native disulfide bonds have been used to induce two short linear segments of the protein into an amphipathic helix. The resulting 13- and 9-residue peptides are significantly more active than their linear counterparts and have an activity similar to that of native thionin.
More information
| Item ID: | 7623 |
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| DC Identifier: | https://oa.upm.es/7623/ |
| OAI Identifier: | oai:oa.upm.es:7623 |
| DOI: | 10.1021/jm050882i |
| Official URL: | http://pubs.acs.org/doi/abs/10.1021/jm050882i |
| Deposited by: | Memoria Investigacion |
| Deposited on: | 20 Jun 2011 07:56 |
| Last Modified: | 22 Sep 2014 10:31 |
