Preparación de nanopartículas y andamios para la cura de heridas y regeneración de la piel

Abstract

Nanomaterials arouse interest in various fields of science and industry due to their unique properties, composition-tunable properties, and the ease of modification.

On the other hand, skin wounds healing presents substantial clinical hurdles, one of which involves the potential susceptibility to bacterial infection. That is why efforts have been made to explore novel therapeutic products based on nanomaterials.

Chitosan, a naturally derived polymeric biomaterial obtained from chitin, has garnered significant interest in promoting skin wound healing, thanks to its antimicrobial and tissue regeneration properties. Additionally, metal nanoparticles such as silver (Ag), gold (Au), and iron oxides (Fe3O4) have demonstrated therapeutic potential for skincare applications due to their unique characteristics. Combining these two promising materials, chitosan and inorganic nanoparticles, holds great promise for creating nanohybrids with enhanced properties, offering potential advancements in advanced skin treatment.

In addition, scaffolds were prepared using polysaccharides, collagen derivatives and polyalcohols, to enhance the properties and stability of the prepared nanoparticles over an extended period.

We performed various assays to measure the beneficial properties of these nanoparticles and scaffolds as agents for skin wound healing and regeneration. These included chemical physical characterization, release assays, measurement of antioxidant and antibacterial activity, cytotoxicity, and cellular regeneration.

We have demonstrated favorable properties in aiding skin regeneration in the mentioned assays.