?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Predictor+param%C3%A9trico+de+glucosa+subcut%C3%A1nea&rft.creator=Garc%C3%ADa+Gonz%C3%A1lez%2C+Carlos&rft.contributor=Rodr%C3%ADguez+Herrero%2C+Agust%C3%ADn&rft.subject=Electronics&rft.description=La+diabetes+mellitus+es+una+enfermedad+que+se+caracteriza+por+la+nula+o+insuficiente+producci%C3%B3n+de+insulina%2C+o+la+resistencia+del+organismo+a+la+misma.+La+insulina+es+una+hormona+que+ayuda+a+que+la+glucosa+(por+ejemplo+la+obtenida+a+partir+de+los+alimentos+ingeridos)+llegue+a+los+tejidos+perif%C3%A9ricos+y+al+sistema+nervioso+para+suministrar+energ%C3%ADa.%0D%0AHoy+en+d%C3%ADa+la+tecnolog%C3%ADa+actual+permite+abordar+el+desarrollo+del+llamado+%E2%80%9Cp%C3%A1ncreas+endocrino+artificial%E2%80%9D%2C+que+consta+de+un+sensor+continuo+de+glucosa+subcut%C3%A1nea%2C+una+bomba+de+infusi%C3%B3n+subcut%C3%A1nea+de+insulina+y+un+algoritmo+de+control+en+lazo+cerrado+que+calcule+la+dosis+de+insulina+requerida+por+el+paciente+en+cada+momento%2C+seg%C3%BAn+la+medida+de+glucosa+obtenida+por+el+sensor+y+seg%C3%BAn+unos+objetivos.%0D%0AEl+mayor+problema+que+presentan+los+sistemas+de+control+en+lazo+cerrado+son+los+retardos%2C+el+sensor+de+glucosa+subcut%C3%A1nea+mide+la+glucosa+del+l%C3%ADquido+intersticial%2C+que%0D%0Arepresenta+la+que+hubo+en+la+sangre+un+tiempo+atr%C3%A1s%2C+por+tanto%2C+un+cambio+en+los+niveles+de+glucosa+en+la+sangre%2C+debidos+por+ejemplo%2C+a+una+ingesta%2C+tardar%C3%ADa+un+tiempo+en+ser+detectado+por+el+sensor.+Adem%C3%A1s%2C+una+dosis+de+insulina+suministrada+al+paciente%2C+tarda+un+tiempo+aproximado+de+20-30+minutos+para+la+llegar+a+la+sangre.%0D%0APara+evitar+trabajar+en+la+medida+que+sea+posible+con+estos+retardos%2C+se+intenta+predecir+cu%C3%A1l+ser%C3%A1+el+nivel+de+glucosa+en+un+futuro+pr%C3%B3ximo%2C+para+ello+se+utilizara+un+predictor+de+glucosa+subcut%C3%A1nea%2C+con+la+informaci%C3%B3n+disponible+de+glucosa+e+insulina.%0D%0AEl+objetivo+del+proyecto+es+dise%C3%B1ar+una+metodolog%C3%ADa+para+estimar+el+valor+futuro+de+los+niveles+de+glucosa+obtenida+a+partir+de+un+sensor+subcut%C3%A1neo%2C+basada+en+la+identificaci%C3%B3n+recursiva+del+sistema+glucorregulatorio+a+trav%C3%A9s+de+modelos+lineales+y+determinando+un+horizonte+de+predicci%C3%B3n+%C3%B3ptimo+de+trabajo+y+analizando+la+influencia+de%0D%0Ala+insulina+en+los+resultados+de+la+predicci%C3%B3n.%0D%0ASe+ha+implementado+un+predictor+param%C3%A9trico+basado+en+un+modelo+autorregresivo+ARX+que+predice+con+mejor+precisi%C3%B3n+y+con+menor+RMSE+que+un+predictor+ZOH+a+un+horizonte+de+predicci%C3%B3n+de+treinta+minutos.+Utilizar+informaci%C3%B3n+relativa+a+la+insulina+no+tiene+efecto+en+la+predicci%C3%B3n.+El+preprocesado%2C+postprocesado+y+el+tratamiento+de+la+estabilidad+tienen+un+efecto+muy+beneficioso+en+la+predicci%C3%B3n.%0D%0ADiabetes+mellitusis+a+group+of+metabolic+diseases+in+which+a+person+has+high+blood+sugar%2C+either+because+the+body+does+not+produce+enough+insulin%2C+or+because+cells+do+not+respond+to+the+insulin+produced.+The+insulin+is+a+hormone+that+helps+the+glucose+to+reach+to+outlying+tissues+and+the+nervous+system+to+supply+energy.%0D%0ANowadays%2C+the+actual+technology+allows+raising+the+development+of+the+%E2%80%9Cartificial+endocrine+pancreas%E2%80%9D.+It+involves+a+continuous+glucose+sensor%2C+an+insulin+bump%2C+and+a+full+closed+loop+algorithm+that+calculate+the+insulin+units+required+by+patient+at+any+time%2C+according+to+the+glucose+measure+obtained+by+the+sensor+and+any+target.%0D%0AThe+main+problem+of+the+full+closed+loop+systems+is+the+delays%2C+the+glucose+sensor+measures+the+glucose+in+the+interstitial+fluid+that+represents+the+glucose+was+in+the+blood+some+time+ago.+Because+of+this%2C+a+change+in+the+glucose+in+blood+would+take+some+time+to+be+detected+by+the+sensor.+In+addition%2C+insulin+units+administered+by+a+patient+take+about+20-30+minutes+to+reach+the+blood+stream.%0D%0AIn+order+to+avoid+this+effect%2C+it+will+try+to+predict+the+glucose+level+in+the+near+future.%0D%0ATo+do+that%2C+a+subcutaneous+glucose+predictor+is+used+to+predict+the+future+glucose+with+the+information+about+insulin+and+glucose.%0D%0AThe+goal+of+the+proyect+is+to+design+a+method+in+order+to+estimate+the+future+valor+of+glucose+obtained+by+a+subcutaneous+sensor.+It+is+based+on+the+recursive+identification+of+the+regulatory+system+through+the+linear+models%2C+determining+optimal+prediction+horizon+and+analyzing+the+influence+of+insuline+on+the+prediction+results.%0D%0AA+parametric+predictor+based+in+ARX+autoregressive+model+predicts+with+better+precision+and+with+lesser+RMSE+than+ZOH+predictor+in+a+thirty+minutes+prediction+horizon.%0D%0AUsing+the+relative+insulin+information+has+no+effect+in+the+prediction.+The+preprocessing%2C+the+postprocessing+and+the+stability+treatment+have+many+advantages+in+the+prediction.&rft.publisher=E.U.I.T.+Telecomunicaci%C3%83%C2%B3n+(UPM)&rft.rights=https%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F3.0%2Fes%2F&rft.date=2012-09-28&rft.type=info%3Aeu-repo%2Fsemantics%2FbachelorThesis&rft.type=Final+Project&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=spa&rft.rights=info%3Aeu-repo%2Fsemantics%2FopenAccess&rft.identifier=https%3A%2F%2Foa.upm.es%2F13975%2F