TY  - JOUR
SP  - 109
TI  - Assembling models of embryo development: Image analysis and the construction of digital atlases
AV  - public
N2  - Digital atlases of animal development provide a quantitative description of morphogenesis, opening the path toward processes modeling. Prototypic atlases offer a data integration framework where to gather information from cohorts of individuals with phenotypic variability. Relevant information for further theoretical reconstruction includes measurements in time and space for cell behaviors and gene expression. The latter as well as data integration in a prototypic model, rely on image processing strategies. Developing the tools to integrate and analyze biological multidimensional data are highly relevant for assessing chemical toxicity or performing drugs preclinical testing. This article surveys some of the most prominent efforts to assemble these prototypes, categorizes them according to salient criteria and discusses the key questions in the field and the future challenges toward the reconstruction of multiscale dynamics in model organisms.
VL  - 96
Y1  - 2012/06//
JF  - Birth Defects Research Part C
EP  - 120
PB  - Wiley
ID  - upm15215
SN  - 1542-9768
UR  - http://onlinelibrary.wiley.com/doi/10.1002/bdrc.21012/full
A1  - Castro González, Carlos
A1  - Ledesma Carbayo, María Jesús
A1  - Peyrieras, Nadine
A1  - Santos Lleo, Andres de
IS  - 2
ER  -