eprintid: 15215 rev_number: 37 eprint_status: archive userid: 1903 dir: disk0/00/01/52/15 datestamp: 2013-06-10 19:23:11 lastmod: 2017-01-17 12:23:34 status_changed: 2017-01-17 12:23:34 type: article metadata_visibility: show item_issues_count: 0 creators_name: Castro González, Carlos creators_name: Ledesma Carbayo, María Jesús creators_name: Peyrieras, Nadine creators_name: Santos Lleo, Andres de title: Assembling models of embryo development: Image analysis and the construction of digital atlases ispublished: pub subjects: telecomunicaciones abstract: Digital atlases of animal development provide a quantitative description of morphogenesis, opening the path toward processes modeling. Prototypic atlases offer a data integration framework where to gather information from cohorts of individuals with phenotypic variability. Relevant information for further theoretical reconstruction includes measurements in time and space for cell behaviors and gene expression. The latter as well as data integration in a prototypic model, rely on image processing strategies. Developing the tools to integrate and analyze biological multidimensional data are highly relevant for assessing chemical toxicity or performing drugs preclinical testing. This article surveys some of the most prominent efforts to assemble these prototypes, categorizes them according to salient criteria and discusses the key questions in the field and the future challenges toward the reconstruction of multiscale dynamics in model organisms. date: 2012-06 date_type: published publisher: Wiley official_url: http://onlinelibrary.wiley.com/doi/10.1002/bdrc.21012/full id_number: 10.1002/bdrc.21012 full_text_status: public publication: Birth Defects Research Part C volume: 96 number: 2 pagerange: 109-120 institution: Telecomunicacion department: Ingenieria_Electronica refereed: TRUE issn: 1542-9768 rights: by-nc-nd citation: Castro González, Carlos and Ledesma Carbayo, María Jesús and Peyrieras, Nadine and Santos Lleo, Andres de (2012). Assembling models of embryo development: Image analysis and the construction of digital atlases. "Birth Defects Research Part C", v. 96 (n. 2); pp. 109-120. ISSN 1542-9768. https://doi.org/10.1002/bdrc.21012 . document_url: https://oa.upm.es/15215/3/INVE_MEM_2012_116014.pdf