eprintid: 4142
rev_number: 32
eprint_status: archive
userid: 1903
dir: disk0/00/00/41/42
datestamp: 2010-09-17 11:45:38
lastmod: 2016-03-09 12:39:59
status_changed: 2016-03-09 12:39:59
type: conference_item
metadata_visibility: show
item_issues_count: 0
creators_name: Hill, Daniel
creators_name: Sánchez, Benito
creators_name: Griol Barres, Amadeu
creators_name: Maire, Guillaume
creators_name: Dortu, Fabian
creators_name: Vivien, Laurent
creators_name: Stragier, Anne-Sophie
creators_name: Marris-Morini, Delphine
creators_name: Cassan, Eric
creators_name: Kazmierczak, Andrzej
creators_name: Giannone, Domenico
creators_name: Gylfason, Kristinn B.
creators_name: Sohlström, Hans
creators_name: Bañuls, María José
creators_name: González-Pedro, Victoria
creators_name: Maquieira, A.
creators_name: Angulo Barrios, Carlos
creators_name: Holgado Bolaños, Miguel
creators_name: Casquel del Campo, Rafael
creators_id: rafael.casquel@upm.es
title: Ultrahigh Sensitivity Slot-Waveguide Biosensor on a Highly Integrated Chip for Simultaneous Diagnosis of Multiple
ispublished: pub
subjects: telecomunicaciones
subjects: bioquimica
abstract: SABIO is a multidisciplinary project involving the emerging fields of micro-nanotechnology, photonics, fluidics and bio-chemistry, targeting a contribution to the development of intelligent diagnostic equipment through the demonstration of a compact polymer based and silicon-based CMOS-compatible micro-nano system. It integrates optical biosensors for label-free biomolecular recognition based on a novel photonic structure named slot-waveguide with immobilized bimolecular receptors on its surface. The slot-waveguides provide high optical intensity in a sub wavelength-size low refractive index region (slot-region) sandwiched between two high refractive index strips (rails) [1] leading to an enhanced interaction between the optical probe and biomolecular complexes (antibody-antigen). As such a biosensor is predicted to exhibit a surface concentration detection-limit lower than 1 pg/mm2, state-of-the-art in label free integrated optical biosensors, as well as the possibility of multiplexed assay, which, together with reduced reaction volumes, leads to the ability to perform rapid multi-analytesensing and comprehensive tests. This offers the further advantageous possibility of assaying several parameters simultaneously and consequently, statistical analysis of these results can potentially increase the reliability and reduce the measurement uncertainty of a diagnostic over single-parameter assays. In addition, the SABIO micro-nano system device applied to its novel protein-based diagnostic technology has the potential to be fast and easy to use, making routine screening or monitoring of diseases more cost-effective.
date: 2008
date_type: published
publisher: IEEE
official_url: http://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000653
full_text_status: public
pres_type: paper
place_of_pub: EEUU
event_title: Proceedings of Semiconductor Laser Conference, 2008. ISLC 2008. IEEE 21st International
event_location: Sorrento, Italia
event_dates: 14/09/2008-18/09/2008
event_type: conference
institution: Ciencias
department: otro
refereed: TRUE
book_title: Proceedings of Semiconductor Laser Conference, 2008. ISLC 2008. IEEE 21st International
rights: by-nc-nd
citation:   Hill, Daniel and Sánchez, Benito and Griol Barres, Amadeu and Maire, Guillaume and Dortu, Fabian and Vivien, Laurent and Stragier, Anne-Sophie and Marris-Morini, Delphine and Cassan, Eric and Kazmierczak, Andrzej and Giannone, Domenico and Gylfason, Kristinn B. and Sohlström, Hans and Bañuls, María José and González-Pedro, Victoria and Maquieira, A. and Angulo Barrios, Carlos and Holgado Bolaños, Miguel and Casquel del Campo, Rafael  (2008).  Ultrahigh Sensitivity Slot-Waveguide Biosensor on a Highly Integrated Chip for Simultaneous Diagnosis of Multiple.  In: "Proceedings of Semiconductor Laser Conference, 2008. ISLC 2008. IEEE 21st International", 14/09/2008-18/09/2008, Sorrento, Italia.    
document_url: https://oa.upm.es/4142/1/INVE_MEM_2008_58482.pdf