TY  - JOUR
A1  - Tonnesen, Jan
A1  - Gonzalez Seiz, Emma
A1  - Ramos Gomez, Milagros
A1  - Lindval, Olle
A1  - Martinez Serrano, Alberto
A1  - Kokaia, Merab
TI  - Functional properties of the human ventral mesencephalic neural stem cell line hVM1.
AV  - public
N2  - The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions
KW  - Human neural stem cell; Dopaminergic neuron; In vitro; Electrophysiology; Functional properties; Differentiation; Parkinson's disease
JF  - Experimental Neurology
Y1  - 2010/06//
PB  - Elsevier
VL  - 223
SP  - 653
EP  - 653
IS  - 2
UR  - http://www.sciencedirect.com/science/journal/00144886
SN  - 0014-4886
ID  - upm8596
ER  -